Literature DB >> 23605280

Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells.

D M Schumacher1, J Wagner, M Metzler, L Lehmann.   

Abstract

The mutagenicity of the mycotoxin patulin was assessed by the thymidine kinase mutation assay, which is based on point mutations and deletions. Patulin was mutagenic in cultured mouse lymphoma cells and the mutagenicity was significantly increased in cells pretreated with buthionine sulfoximine, which reduces intracellular glutathione levels.

Entities:  

Year:  2005        PMID: 23605280     DOI: 10.1007/BF02954442

Source DB:  PubMed          Journal:  Mycotoxin Res        ISSN: 0178-7888            Impact factor:   3.833


  6 in total

1.  Measurement of thiols in cell populations from tumor and normal tissue.

Authors:  J A Cook; J B Mitchell
Journal:  Methods Enzymol       Date:  1995       Impact factor: 1.600

2.  The mouse lymphoma assay.

Authors:  J Clements
Journal:  Mutat Res       Date:  2000-11-20       Impact factor: 2.433

3.  Electrophilic properties of patulin. Adduct structures and reaction pathways with 4-bromothiophenol and other model nucleophiles.

Authors:  R Fliege; M Metzler
Journal:  Chem Res Toxicol       Date:  2000-05       Impact factor: 3.739

4.  Electrophilic properties of patulin. N-acetylcysteine and glutathione adducts.

Authors:  R Fliege; M Metzler
Journal:  Chem Res Toxicol       Date:  2000-05       Impact factor: 3.739

5.  Mutagenicity of the mycotoxin patulin in cultured Chinese hamster V79 cells, and its modulation by intracellular glutathione.

Authors:  David M Schumacher; Manfred Metzler; Leane Lehmann
Journal:  Arch Toxicol       Date:  2004-11-05       Impact factor: 5.153

6.  Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin.

Authors:  E Pfeiffer; K Gross; M Metzler
Journal:  Carcinogenesis       Date:  1998-07       Impact factor: 4.944

  6 in total
  4 in total

Review 1.  Mycotoxins: cytotoxicity and biotransformation in animal cells.

Authors:  Jikai Wen; Peiqiang Mu; Yiqun Deng
Journal:  Toxicol Res (Camb)       Date:  2016-01-07       Impact factor: 3.524

Review 2.  Toxicological effects of patulin mycotoxin on the mammalian system: an overview.

Authors:  Saurabh Pal; Neha Singh; Kausar Mahmood Ansari
Journal:  Toxicol Res (Camb)       Date:  2017-08-09       Impact factor: 3.524

Review 3.  Biosynthesis and toxicological effects of patulin.

Authors:  Olivier Puel; Pierre Galtier; Isabelle P Oswald
Journal:  Toxins (Basel)       Date:  2010-04-05       Impact factor: 4.546

4.  Crosstalk between proteins expression and lysine acetylation in response to patulin stress in Rhodotorula mucilaginosa.

Authors:  Xiangfeng Zheng; Qiya Yang; Lina Zhao; Maurice Tibiru Apaliya; Xiaoyun Zhang; Hongyin Zhang
Journal:  Sci Rep       Date:  2017-10-18       Impact factor: 4.379

  4 in total

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