PURPOSE: To investigate changes in fundus autofluorescence (FAF) during 3 years of follow-up in patients with polypoidal choroidal vasculopathy (PCV). DESIGN: Retrospective study. METHODS: We retrospectively reviewed the charts of 48 eyes of 47 patients (35 men, 12 women; mean age, 69.9 ± 7.1 years) with treatment-naïve PCV for whom FAF and indocyanine green angiography (ICGA) images were available at baseline and at 3 years ± 3 months follow-up examination. The main outcome measures were the FAF changes during 3 years of follow-up, and the correlation between them and polypoidal lesions and branching vascular networks on ICGA. RESULTS: The FAF of the polypoidal lesions showed three patterns at baseline and changes during 3 years of follow-up: confluent hypoautofluorescence surrounded by a hyperautofluorescent ring (86.1% → 51.4%), confluent hypoautofluorescence without a ring (8.3% → 43.0%), and no marked changes (5.6% → 5.6%). The FAF in 96.2% of resolved polypoidal lesions persisted on images with abnormal FAF during the 3 years of follow-up. The granular hypoautofluorescence at the branching vascular networks at baseline became partially confluent hypoautofluorescence in 41 eyes (85.4%). The mean area with confluent hypoautofluorescence that corresponded to the branching vascular network lesions increased significantly (P < 0.001) from 1.75 mm(2) to 5.10 mm(2) after 3 years of follow-up. CONCLUSION: The FAF changes in PCV during the 3 years of follow-up can indicate that FAF imaging is a useful and clinically beneficial tool for noninvasively evaluating the PCV lesions and disorders of the upper retinal pigment epithelium.
PURPOSE: To investigate changes in fundus autofluorescence (FAF) during 3 years of follow-up in patients with polypoidal choroidal vasculopathy (PCV). DESIGN: Retrospective study. METHODS: We retrospectively reviewed the charts of 48 eyes of 47 patients (35 men, 12 women; mean age, 69.9 ± 7.1 years) with treatment-naïve PCV for whom FAF and indocyanine green angiography (ICGA) images were available at baseline and at 3 years ± 3 months follow-up examination. The main outcome measures were the FAF changes during 3 years of follow-up, and the correlation between them and polypoidal lesions and branching vascular networks on ICGA. RESULTS: The FAF of the polypoidal lesions showed three patterns at baseline and changes during 3 years of follow-up: confluent hypoautofluorescence surrounded by a hyperautofluorescent ring (86.1% → 51.4%), confluent hypoautofluorescence without a ring (8.3% → 43.0%), and no marked changes (5.6% → 5.6%). The FAF in 96.2% of resolved polypoidal lesions persisted on images with abnormal FAF during the 3 years of follow-up. The granular hypoautofluorescence at the branching vascular networks at baseline became partially confluent hypoautofluorescence in 41 eyes (85.4%). The mean area with confluent hypoautofluorescence that corresponded to the branching vascular network lesions increased significantly (P < 0.001) from 1.75 mm(2) to 5.10 mm(2) after 3 years of follow-up. CONCLUSION: The FAF changes in PCV during the 3 years of follow-up can indicate that FAF imaging is a useful and clinically beneficial tool for noninvasively evaluating the PCV lesions and disorders of the upper retinal pigment epithelium.
Authors: Ramzi G Sayegh; Christian Simader; Ulrike Scheschy; Alessio Montuoro; Christopher Kiss; Stefan Sacu; David P Kreil; Christian Prünte; Ursula Schmidt-Erfurth Journal: Ophthalmology Date: 2011-04-15 Impact factor: 12.079
Authors: Emma C Zanzottera; Thomas Ach; Carrie Huisingh; Jeffrey D Messinger; K Bailey Freund; Christine A Curcio Journal: Retina Date: 2016-12 Impact factor: 4.256