Literature DB >> 23603826

5-Fluorouracil augmented needle revision of trabeculectomy: does the location of outflow resistance make a difference?

Andrew Tatham1, Usman Sarodia, Wojciech Karwatowski.   

Abstract

PURPOSE: To determine whether the outcome of needle revision of trabeculectomy is influenced by the presumed anatomic location of resistance to aqueous outflow.
DESIGN: Retrospective case note review. PARTICIPANTS: Thirty-four eyes of 30 consecutive patients undergoing their first needle revision of trabeculectomy.
METHODS: We compared 2 types of needle revision: "type-1 needling," limited to breaking down fibrosis in the subconjuctival-subtenon space, and "type-2 needling," which additionally involved needling underneath the scleral flap. MAIN OUTCOME MEASURES: Unqualified success was defined as a postneedling intraocular pressure (IOP) >4 mm Hg and ≤21 mm Hg at the most recent follow-up without further surgery, medications, or repeat needling. Qualified success was defined as a successful patient who required medications or repeat needling.
RESULTS: The mean follow-up period was 2.1 ± 0.1 years (range, 1.0 to 3.8 y). Sixteen type-1 and 18 type-2 procedures were performed at a median of 124 days (22 d to 14 y) after trabeculectomy. IOP decreased from a mean of 28.2±1.3 mm Hg (19 to 52 mm Hg) preneedling to 6.7±0.8 mm Hg (2 to 22 mm Hg) on the first postoperative visit and 15.1±0.7 mm Hg (8 to 27 mm Hg) at the most recent follow-up. The overall success rate was 82.4% (47.1% unqualified and a further 35.3% qualified). There was no significant difference in the success rates between type-1 (14/16) and type-2 (14/18) needle revisions (Fisher exact test, P=0.66). Similar proportions of eyes undergoing type-1 and type-2 needling underwent a second needling procedure. There was no significant difference in the IOP reduction between type-1 and type-2 needling (Mann-Whitney U test, P=0.78).
CONCLUSIONS: Needle revision is an effective technique for trabeculectomy bleb remodeling and can result in a sustained reduction in IOP. The location of the obstruction did not influence outcome, with type-1 and type-2 needle revisions equally likely to succeed.

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Year:  2013        PMID: 23603826     DOI: 10.1097/IJG.0b013e31824484ce

Source DB:  PubMed          Journal:  J Glaucoma        ISSN: 1057-0829            Impact factor:   2.503


  3 in total

Review 1.  [Revision after filtration surgery].

Authors:  A G M Jünemann; R Rejdak; B Hohberger
Journal:  Ophthalmologe       Date:  2016-11       Impact factor: 1.059

2.  Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up.

Authors:  Andrew S H Tsai; Pui Yi Boey; Hla M Htoon; Tina T Wong
Journal:  Int J Ophthalmol       Date:  2015-08-18       Impact factor: 1.779

3.  Safety and Efficacy of Bleb Needling with Antimetabolite after Trabeculectomy Failure in Glaucoma Patients: A Systemic Review and Meta-Analysis.

Authors:  Xuhao Chen; Lingge Suo; Ying Hong; Chun Zhang
Journal:  J Ophthalmol       Date:  2020-11-30       Impact factor: 1.909

  3 in total

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