AIMS: The purpose of this study was to determine the long-term efficacy and safety of valproic acid (VPA) treatment in patients with pigmentary retinal dystrophies. METHODS: A retrospective chart review was conducted on 31 patients with a diagnosis of pigmentary retinal dystrophy prescribed VPA at a single centre. Visual field (VF), visual acuity (VA), length of treatment, liver enzymes and side effects were analysed. VF areas were defined using Goldmann VF (GVF) tracings recorded before, during and after VPA treatment using the V4e isopter for each eye. Using custom software, planimetric areas of VF were calculated. RESULTS: Five of the patients (10 eyes) had two Goldmann VF tracings, allowing comparison between baseline and follow-up VF. After 9.8 months of VPA, VF decreased by 0.145 cm(2) (26.478%) (p=0.432). For 22 of the patients (41 eyes), VA data was available, and logarithm of the minimum angle of resolution (logMAR) score changed by 0.056 log units (representing a decline in VA) after 14.9 months on VPA (p=0.002). Twelve patients (38.7%) reported negative side effects related to VPA use. CONCLUSIONS: VPA plays a complex role in patients with pigmentary retinal dystrophies and may be associated with VA and field decline as well as adverse side effects. Physicians should use caution with using VPA for pigmentary retinal dystrophies.
AIMS: The purpose of this study was to determine the long-term efficacy and safety of valproic acid (VPA) treatment in patients with pigmentary retinal dystrophies. METHODS: A retrospective chart review was conducted on 31 patients with a diagnosis of pigmentary retinal dystrophy prescribed VPA at a single centre. Visual field (VF), visual acuity (VA), length of treatment, liver enzymes and side effects were analysed. VF areas were defined using Goldmann VF (GVF) tracings recorded before, during and after VPA treatment using the V4e isopter for each eye. Using custom software, planimetric areas of VF were calculated. RESULTS: Five of the patients (10 eyes) had two Goldmann VF tracings, allowing comparison between baseline and follow-up VF. After 9.8 months of VPA, VF decreased by 0.145 cm(2) (26.478%) (p=0.432). For 22 of the patients (41 eyes), VA data was available, and logarithm of the minimum angle of resolution (logMAR) score changed by 0.056 log units (representing a decline in VA) after 14.9 months on VPA (p=0.002). Twelve patients (38.7%) reported negative side effects related to VPA use. CONCLUSIONS:VPA plays a complex role in patients with pigmentary retinal dystrophies and may be associated with VA and field decline as well as adverse side effects. Physicians should use caution with using VPA for pigmentary retinal dystrophies.
Authors: Michael P Barry; Ava K Bittner; Liancheng Yang; Rebecca Marcus; Mian Haris Iftikhar; Gislin Dagnelie Journal: Optom Vis Sci Date: 2016-07 Impact factor: 1.973
Authors: Ruanne Y J Vent-Schmidt; Runxia H Wen; Zusheng Zong; Colette N Chiu; Beatrice M Tam; Christopher G May; Orson L Moritz Journal: J Neurosci Date: 2017-01-25 Impact factor: 6.167
Authors: David G Birch; Paul S Bernstein; Alessandro Iannacone; Mark E Pennesi; Byron L Lam; John Heckenlively; Karl Csaky; Mary Elizabeth Hartnett; Kevin L Winthrop; Thiran Jayasundera; Dianna K Hughbanks-Wheaton; Judith Warner; Paul Yang; Gary Edd Fish; Michael P Teske; Neal L Sklaver; Laura Erker; Elvira Chegarnov; Travis Smith; Aimee Wahle; Paul C VanVeldhuisen; Jennifer McCormack; Robert Lindblad; Steven Bramer; Stephen Rose; Patricia Zilliox; Peter J Francis; Richard G Weleber Journal: JAMA Ophthalmol Date: 2018-08-01 Impact factor: 7.389
Authors: Yuanyuan Chen; Matthew J Brooks; Linn Gieser; Anand Swaroop; Krzysztof Palczewski Journal: Pharmacol Res Date: 2016-11-09 Impact factor: 7.658