Literature DB >> 23603270

Design of net-charged abc-type collagen heterotrimers.

Avanish S Parmar1, Sohail Zahid1, Sandeep V Belure1, Robert Young1, Nida Hasan1, Vikas Nanda2.   

Abstract

Net-negatively-charged heterospecific A:B:C collagen peptide heterotrimers were designed using an automated computational approach. The design algorithm considers both target stability and the energy gap between the target states and misfolded competing states. Structural characterization indicates the net-negative charge balance on the new designs enhances the specificity of the target state at the expense of its stability.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Collagen; Electrostatics; Protein design; Triple-helix

Mesh：

Substances：

Year:  2013        PMID： 23603270      PMCID： PMC3874424          DOI： 10.1016/j.jsb.2013.04.006

Source DB:  PubMed          Journal:  J Struct Biol        ISSN： 1047-8477            Impact factor:   2.867


  35 in total

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3.  Improving coiled-coil stability by optimizing ionic interactions.

Authors:  Peter Burkhard; Sergei Ivaninskii; Ariel Lustig
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4.  Design of a novel globular protein fold with atomic-level accuracy.

Authors:  Brian Kuhlman; Gautam Dantas; Gregory C Ireton; Gabriele Varani; Barry L Stoddard; David Baker
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5.  Computational de novo design, and characterization of an A(2)B(2) diiron protein.

Authors:  Christopher M Summa; Michael M Rosenblatt; Jae-Kyoung Hong; James D Lear; William F DeGrado
Journal:  J Mol Biol       Date:  2002-08-30       Impact factor: 5.469

6.  X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.

Authors:  E K O'Shea; J D Klemm; P S Kim; T Alber
Journal:  Science       Date:  1991-10-25       Impact factor: 47.728

7.  Effect of temperature on the circular dichroism spectra of polypeptides in the extended state.

Authors:  M L Tiffany; S Krimm
Journal:  Biopolymers       Date:  1972       Impact factor: 2.505

8.  Peptide investigations of pairwise interactions in the collagen triple-helix.

Authors:  Anton V Persikov; John A M Ramshaw; Alan Kirkpatrick; Barbara Brodsky
Journal:  J Mol Biol       Date:  2002-02-15       Impact factor: 5.469

9.  Sequence recombination improves target specificity in a redesigned collagen peptide abc-type heterotrimer.

Authors:  Sumana Giddu; Fei Xu; Vikas Nanda
Journal:  Proteins       Date:  2012-11-05

10.  The triple helix in equilibrium with coil conversion of collagen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L-Pro-L-Pro-Gly)n and (L-Pro-L-Hyp-Gly)n.

Authors:  J Engel; H T Chen; D J Prockop; H Klump
Journal:  Biopolymers       Date:  1977-03       Impact factor: 2.505
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  2 in total

1.  Empirical estimation of local dielectric constants: Toward atomistic design of collagen mimetic peptides.

Authors:  Douglas H Pike; Vikas Nanda
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

2.  Control of Collagen Stability and Heterotrimer Specificity through Repulsive Electrostatic Interactions.

Authors:  Avanish S Parmar; Mihir Joshi; Patrick L Nosker; Nida F Hasan; Vikas Nanda
Journal:  Biomolecules       Date:  2013-12-06
  2 in total

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