OBJECTIVE: To test the applicability of the sex-specific 2008 Framingham general cardiovascular risk equation for coronary heart disease (CHD) and stroke in European middle-aged men from Ireland and France. METHODS: In the PRIME study, 9638 healthy middle-aged men recruited in France and Ireland were surveyed for 10 years for the occurrence of first CHD and stroke events. The original Framingham equation, the partially calibrated Framingham equation (using the PRIME baseline survival at 10 years), and the completely calibrated Framingham equation (additionally using risk factor means calculated in PRIME) were assessed. Model fit (expected versus observed events) and discrimination ability were assessed using a modified Hosmer-Lemeshow Chi-square statistic and Harrell's c-index respectively. RESULTS: The original (uncalibrated) Framingham equation overestimated by 1.94-fold the risk of CHD and stroke combined in PRIME, and by 2.23 and 1.42-fold in PRIME-France and PRIME-Ireland respectively. Adequate fit was found after complete calibration. However, discrimination ability of the Framingham equation was poor as shown by Harrell's c-index lower than 0.70. CONCLUSION: The (completely) calibrated 2008 Framingham equation predicted accurate number of CHD and stroke events but discriminated poorly individuals at higher from those at lower event risk in a European population of middle-aged men.
OBJECTIVE: To test the applicability of the sex-specific 2008 Framingham general cardiovascular risk equation for coronary heart disease (CHD) and stroke in European middle-aged men from Ireland and France. METHODS: In the PRIME study, 9638 healthy middle-aged men recruited in France and Ireland were surveyed for 10 years for the occurrence of first CHD and stroke events. The original Framingham equation, the partially calibrated Framingham equation (using the PRIME baseline survival at 10 years), and the completely calibrated Framingham equation (additionally using risk factor means calculated in PRIME) were assessed. Model fit (expected versus observed events) and discrimination ability were assessed using a modified Hosmer-Lemeshow Chi-square statistic and Harrell's c-index respectively. RESULTS: The original (uncalibrated) Framingham equation overestimated by 1.94-fold the risk of CHD and stroke combined in PRIME, and by 2.23 and 1.42-fold in PRIME-France and PRIME-Ireland respectively. Adequate fit was found after complete calibration. However, discrimination ability of the Framingham equation was poor as shown by Harrell's c-index lower than 0.70. CONCLUSION: The (completely) calibrated 2008 Framingham equation predicted accurate number of CHD and stroke events but discriminated poorly individuals at higher from those at lower event risk in a European population of middle-aged men.
Authors: J Bousquet; D Kuh; M Bewick; T Standberg; J Farrell; R Pengelly; M E Joel; L Rodriguez Mañas; J Mercier; J Bringer; T Camuzat; R Bourret; A Bedbrook; M L Kowalski; B Samolinski; S Bonini; C Brayne; J P Michel; J Venne; P Viriot-Durandal; J Alonso; A Avignon; Y Ben-Shlomo; P J Bousquet; B Combe; R Cooper; R Hardy; G Iaccarino; T Keil; E Kesse-Guyot; I Momas; K Ritchie; J M Robine; C Thijs; C Tischer; B Vellas; A Zaidi; F Alonso; K Andersen Ranberg; V Andreeva; J Ankri; S Arnavielhe; H Arshad; P Augé; C Berr; P Bertone; H Blain; A Blasimme; G J Buijs; D Caimmi; A Carriazo; A Cesario; J Coletta; T Cosco; M Criton; F Cuisinier; P Demoly; S Fernandez-Nocelo; B Fougère; J Garcia-Aymerich; M Goldberg; N Guldemond; Z Gutter; D Harman; A Hendry; D Heve; M Illario; C Jeandel; S Krauss-Etschmann; O Krys; D Kula; D Laune; S Lehmann; D Maier; J Malva; P Matignon; E Melen; G Mercier; G Moda; A Nizinkska; M Nogues; M O'Neill; J Y Pelissier; D Poethig; D Porta; D Postma; F Puisieux; M Richards; C Robalo-Cordeiro; V Romano; F Roubille; H Schulz; A Scott; P Senesse; S Slagter; H A Smit; D Somekh; M Stafford; J Suanzes; A Todo-Bom; J Touchon; V Traver-Salcedo; M Van Beurden; R Varraso; I Vergara; E Villalba-Mora; N Wilson; E Wouters; M Zins Journal: J Nutr Health Aging Date: 2015-11 Impact factor: 4.075
Authors: Thomas P A Debray; Richard D Riley; Maroeska M Rovers; Johannes B Reitsma; Karel G M Moons Journal: PLoS Med Date: 2015-10-13 Impact factor: 11.069
Authors: Priya Parmar; Rita Krishnamurthi; M Arfan Ikram; Albert Hofman; Saira S Mirza; Yury Varakin; Michael Kravchenko; Michael Piradov; Amanda G Thrift; Bo Norrving; Wenzhi Wang; Dipes Kumar Mandal; Suzanne Barker-Collo; Ramesh Sahathevan; Stephen Davis; Gustavo Saposnik; Miia Kivipelto; Shireen Sindi; Natan M Bornstein; Maurice Giroud; Yannick Béjot; Michael Brainin; Richie Poulton; K M Venkat Narayan; Manuel Correia; António Freire; Yoshihiro Kokubo; David Wiebers; George Mensah; Nasser F BinDhim; P Alan Barber; Jeyaraj Durai Pandian; Graeme J Hankey; Man Mohan Mehndiratta; Shobhana Azhagammal; Norlinah Mohd Ibrahim; Max Abbott; Elaine Rush; Patria Hume; Tasleem Hussein; Rohit Bhattacharjee; Mitali Purohit; Valery L Feigin Journal: Int J Stroke Date: 2014-12-10 Impact factor: 5.266
Authors: Paulo Marcos Matta Guedes; Cléber Mesquita de Andrade; Daniela Ferreira Nunes; Nathalie de Sena Pereira; Tamyres Bernadete Dantas Queiroga; George Luiz Lins Machado-Coelho; Manuela Sales Lima Nascimento; Maria Adelaide Do-Valle-Matta; Antônia Cláudia Jácome da Câmara; Egler Chiari; Lúcia Maria da Cunha Galvão Journal: PLoS Negl Trop Dis Date: 2016-04-26