Literature DB >> 23602624

Perspectives in targeting miRNA function.

Christiane Schöniger1, Christoph Arenz.   

Abstract

First oligonucleotide analogues that inhibit miRNA function are currently investigated in clinical trials. In addition, several alternative methods are under development that may allow for controlling miRNA function by small molecules-mediated inhibiting of its biogenesis. In this perspectives article, we provide a short overview on recent developments in this field.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antagomirs; High throughput screening; Small molecules; miRNA

Mesh：

Substances：

Year:  2013        PMID： 23602624     DOI： 10.1016/j.bmc.2013.03.040

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Construction of pancreatic cancer double-factor regulatory network based on chip data on the transcriptional level.

Authors:  Li-Li Zhao; Tong Zhang; Bing-Rong Liu; Tie-Fu Liu; Na Tao; Li-Wei Zhuang
Journal:  Mol Biol Rep       Date:  2014-01-28       Impact factor: 2.316

Review 2.  Structure based approaches for targeting non-coding RNAs with small molecules.

Authors:  Matthew D Shortridge; Gabriele Varani
Journal:  Curr Opin Struct Biol       Date:  2015-02-16       Impact factor: 6.809

3.  A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing.

Authors:  Matthew D Shortridge; Matthew J Walker; Tom Pavelitz; Yu Chen; Wen Yang; Gabriele Varani
Journal:  ACS Chem Biol       Date:  2017-05-02       Impact factor: 5.100

4.  miR-196 acts as a tumor suppressor in osteosarcoma by targeting HOXA9.

Authors:  Yang Cao; Binqi Wu; Dawei Wang; Zhenggang Bi
Journal:  Int J Clin Exp Pathol       Date:  2018-09-01

5.  NMR characterization of an oligonucleotide model of the miR-21 pre-element.

Authors:  Sara Chirayil; Qiong Wu; Carlos Amezcua; Kevin J Luebke
Journal:  PLoS One       Date:  2014-09-24       Impact factor: 3.240

6.  Monitoring Dicer-Mediated miRNA-21 Maturation and Ago2 Loading by a Dual-Colour FIT PNA Probe Set.

Authors:  Natalia Loibl; Christoph Arenz; Oliver Seitz
Journal:  Chembiochem       Date:  2020-05-26       Impact factor: 3.164

7.  MicroRNA-152 Acts as a Tumor Suppressor MicroRNA by Inhibiting Krüppel-Like Factor 5 in Human Cervical Cancer.

Authors:  Haiyan Zhang; Yanxia Lu; Surong Wang; Xiugui Sheng; Shiqian Zhang
Journal:  Oncol Res       Date:  2018-08-21       Impact factor: 5.574
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.