Literature DB >> 23602427

HIV-1 envelope glycoprotein structure.

Alan Merk1, Sriram Subramaniam.   

Abstract

The trimeric envelope glycoprotein of HIV-1, composed of gp120 and gp41 subunits, remains a major target for vaccine development. The structures of the core regions of monomeric gp120 and gp41 have been determined previously by X-ray crystallography. New insights into the structure of trimeric HIV-1 envelope glycoproteins are now coming from cryo-electron tomographic studies of the gp120/gp41 trimer as displayed on intact viruses and from cryo-electron microscopic studies of purified, soluble versions of the ectodomain of the trimer. Here, we review recent developments in these fields as they relate to our understanding of the structure and function of HIV-1 envelope glycoproteins. Published by Elsevier Ltd.

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Year:  2013        PMID： 23602427      PMCID： PMC3676719          DOI： 10.1016/j.sbi.2013.03.007

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  81 in total

1.  Solution structure, conformational dynamics, and CD4-induced activation in full-length, glycosylated, monomeric HIV gp120.

Authors:  Miklos Guttman; Maria Kahn; Natalie K Garcia; Shiu-Lok Hu; Kelly K Lee
Journal:  J Virol       Date:  2012-06-06       Impact factor: 5.103

2.  Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging.

Authors:  Gabriel A Frank; Alberto Bartesaghi; Oleg Kuybeda; Mario J Borgnia; Tommi A White; Guillermo Sapiro; Sriram Subramaniam
Journal:  J Struct Biol       Date:  2012-01-10       Impact factor: 2.867

3.  Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.

Authors:  Jason S McLellan; Marie Pancera; Chris Carrico; Jason Gorman; Jean-Philippe Julien; Reza Khayat; Robert Louder; Robert Pejchal; Mallika Sastry; Kaifan Dai; Sijy O'Dell; Nikita Patel; Syed Shahzad-ul-Hussan; Yongping Yang; Baoshan Zhang; Tongqing Zhou; Jiang Zhu; Jeffrey C Boyington; Gwo-Yu Chuang; Devan Diwanji; Ivelin Georgiev; Young Do Kwon; Doyung Lee; Mark K Louder; Stephanie Moquin; Stephen D Schmidt; Zhi-Yong Yang; Mattia Bonsignori; John A Crump; Saidi H Kapiga; Noel E Sam; Barton F Haynes; Dennis R Burton; Wayne C Koff; Laura M Walker; Sanjay Phogat; Richard Wyatt; Jared Orwenyo; Lai-Xi Wang; James Arthos; Carole A Bewley; John R Mascola; Gary J Nabel; William R Schief; Andrew B Ward; Ian A Wilson; Peter D Kwong
Journal:  Nature       Date:  2011-11-23       Impact factor: 49.962

4.  Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.

Authors:  Young Do Kwon; Andrés Finzi; Xueling Wu; Cajetan Dogo-Isonagie; Lawrence K Lee; Lucas R Moore; Stephen D Schmidt; Jonathan Stuckey; Yongping Yang; Tongqing Zhou; Jiang Zhu; David A Vicic; Asim K Debnath; Lawrence Shapiro; Carole A Bewley; John R Mascola; Joseph G Sodroski; Peter D Kwong
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

5.  A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.

Authors:  Robert Pejchal; Katie J Doores; Laura M Walker; Reza Khayat; Po-Ssu Huang; Sheng-Kai Wang; Robyn L Stanfield; Jean-Philippe Julien; Alejandra Ramos; Max Crispin; Rafael Depetris; Umesh Katpally; Andre Marozsan; Albert Cupo; Sebastien Maloveste; Yan Liu; Ryan McBride; Yukishige Ito; Rogier W Sanders; Cassandra Ogohara; James C Paulson; Ten Feizi; Christopher N Scanlan; Chi-Huey Wong; John P Moore; William C Olson; Andrew B Ward; Pascal Poignard; William R Schief; Dennis R Burton; Ian A Wilson
Journal:  Science       Date:  2011-10-13       Impact factor: 47.728

6.  Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.

Authors:  Judith M LaLonde; Young Do Kwon; David M Jones; Alexander W Sun; Joel R Courter; Takahiro Soeta; Toyoharu Kobayashi; Amy M Princiotto; Xueling Wu; Arne Schön; Ernesto Freire; Peter D Kwong; John R Mascola; Joseph Sodroski; Navid Madani; Amos B Smith
Journal:  J Med Chem       Date:  2012-04-23       Impact factor: 7.446

Review 7.  The molecular basis of HIV entry.

Authors:  Per Johan Klasse
Journal:  Cell Microbiol       Date:  2012-06-05       Impact factor: 3.715

8.  Increasing the potency and breadth of an HIV antibody by using structure-based rational design.

Authors:  Ron Diskin; Johannes F Scheid; Paola M Marcovecchio; Anthony P West; Florian Klein; Han Gao; Priyanthi N P Gnanapragasam; Alexander Abadir; Michael S Seaman; Michel C Nussenzweig; Pamela J Bjorkman
Journal:  Science       Date:  2011-10-27       Impact factor: 47.728

9.  Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.

Authors:  Joel R Meyerson; Tommi A White; Donald Bliss; Amy Moran; Alberto Bartesaghi; Mario J Borgnia; M Jason V de la Cruz; David Schauder; Lisa M Hartnell; Rachna Nandwani; Moez Dawood; Brianna Kim; Jun Hong Kim; John Sununu; Lisa Yang; Siddhant Bhatia; Carolyn Subramaniam; Darrell E Hurt; Laurent Gaudreault; Sriram Subramaniam
Journal:  J Vis Exp       Date:  2011-12-01       Impact factor: 1.355

10.  Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.

Authors:  Erin E H Tran; Mario J Borgnia; Oleg Kuybeda; David M Schauder; Alberto Bartesaghi; Gabriel A Frank; Guillermo Sapiro; Jacqueline L S Milne; Sriram Subramaniam
Journal:  PLoS Pathog       Date:  2012-07-12       Impact factor: 6.823
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  39 in total

1.  Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.

Authors:  Dmitry Lyumkis; Jean-Philippe Julien; Natalia de Val; Albert Cupo; Clinton S Potter; Per-Johan Klasse; Dennis R Burton; Rogier W Sanders; John P Moore; Bridget Carragher; Ian A Wilson; Andrew B Ward
Journal:  Science       Date:  2013-10-31       Impact factor: 47.728

2.  Honing a harder-hitting hammerhead improves broadly neutralizing antibody breadth and potency.

Authors:  George K Lewis
Journal:  J Clin Invest       Date:  2015-05-18       Impact factor: 14.808

Review 3.  Methods for gene transfer to the central nervous system.

Authors:  Boris Kantor; Rachel M Bailey; Keon Wimberly; Sahana N Kalburgi; Steven J Gray
Journal:  Adv Genet       Date:  2014       Impact factor: 1.944

4.  Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States.

Authors:  Jeremiah D Heredia; Jihye Park; Hannah Choi; Kevin S Gill; Erik Procko
Journal:  J Virol       Date:  2019-05-15       Impact factor: 5.103

5.  Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding.

Authors:  Julien Roche; John M Louis; Annie Aniana; Rodolfo Ghirlando; Ad Bax
Journal:  J Biomol NMR       Date:  2015-01-29       Impact factor: 2.835

6.  Intra-spike crosslinking overcomes antibody evasion by HIV-1.

Authors:  Rachel P Galimidi; Joshua S Klein; Maria S Politzer; Shiyu Bai; Michael S Seaman; Michel C Nussenzweig; Anthony P West; Pamela J Bjorkman
Journal:  Cell       Date:  2015-01-29       Impact factor: 41.582

7.  Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.

Authors:  Julien Roche; John M Louis; Alexander Grishaev; Jinfa Ying; Adriaan Bax
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

8.  Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.

Authors:  Soraya Serrano; Aitziber Araujo; Beatriz Apellániz; Steve Bryson; Pablo Carravilla; Igor de la Arada; Nerea Huarte; Edurne Rujas; Emil F Pai; José L R Arrondo; Carmen Domene; María Angeles Jiménez; José L Nieva
Journal:  J Biol Chem       Date:  2014-01-15       Impact factor: 5.157

9.  The importance of seeing surface (effects).

Authors:  James M Gruschus; R Andrew Byrd; Paul A Randazzo
Journal:  Structure       Date:  2014-03-04       Impact factor: 5.006

Review 10.  The role of matrix in HIV-1 envelope glycoprotein incorporation.

Authors:  Philip R Tedbury; Eric O Freed
Journal:  Trends Microbiol       Date:  2014-06-02       Impact factor: 17.079
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