Literature DB >> 23601795

The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.

Fabiana Barzotti Kohlrausch1, Clarissa Severino-Gama, Maria Inês Lobato, Paulo Belmonte-de-Abreu, Angel Carracedo, Mara Helena Hutz.   

Abstract

We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.
© 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Adverse effects; Cytochrome; Pharmacogenetics

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Year:  2013        PMID： 23601795     DOI： 10.1016/j.psychres.2013.02.030

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  4 in total

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Journal:  BMC Psychiatry       Date:  2014-02-20       Impact factor: 3.630

4.  The effect of CYP1A2 gene polymorphism on the metabolism of theophylline.

Authors:  Shijuan Xiong; Lingling Li
Journal:  Exp Ther Med       Date:  2017-10-30       Impact factor: 2.447
  4 in total

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