Stefania Crotti1, Giorgio A Iotti2, Alfredo Lissoni3, Mirko Belliato2, Marinella Zanierato4, Monica Chierichetti3, Guendalina Di Meo2, Federica Meloni5, Marilena Pappalettera6, Mario Nosotti7, Luigi Santambrogio7, Mario Viganò8, Antonio Braschi4, Luciano Gattinoni9. 1. Dipartimento di Anestesia, Rianimazione (Intensiva e Subintensiva) e Terapia del Dolore, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan, Milan. Electronic address: stefania.crotti@policlinico.mi.it. 2. Anestesia e Rianimazione 2, Fondazione IRCCS Policlinico S. Matteo, Pavia. 3. Dipartimento di Anestesia, Rianimazione (Intensiva e Subintensiva) e Terapia del Dolore, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan, Milan. 4. Anestesia e Rianimazione 1, Fondazione IRCCS Policlinico S. Matteo, Pavia. 5. Pneumologia, Fondazione IRCCS Policlinico S. Matteo, Pavia; Dipartimento di Medicina Molecolare, Università degli Studi, Pavia, Italy. 6. Respiratory Medicine Section, Dipartimento Toraco-Polmonare e Cardiocircolatorio, Università degli Studi, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan. 7. Operative Unit for Thoracic Surgery and Lung Transplantation, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan, Milan. 8. Cardiochirurgia, Fondazione IRCCS Policlinico S. Matteo, Pavia. 9. Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Università degli Studi, Milan; Dipartimento di Scienze Clinico-chirurgiche, Diagnostiche e Pediatriche, Università degli Studi, Pavia, Italy.
Abstract
BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplant (LTX) is still being debated. METHODS: We performed a retrospective two-center analysis of the relationship between ECMO bridging duration and survival in 25 patients. Further survival analysis was obtained by dividing the patients according to waiting time on ECMO: up to 14 days (Early group) or longer (Late group). We also analyzed the impact of the ventilation strategy during ECMO bridging (ie, spontaneous breathing and noninvasive ventilation [NIV] or intubation and invasive mechanical ventilation [IMV]). RESULTS: Seventeen of 25 patients underwent a transplant (with a 76% 1-year survival), whereas eight patients died during bridging. In the 17 patients who underwent a transplant, mortality was positively related to waiting days until LTX (hazard ratio [HR], 1.12 per day; 95% CI, 1.02-1.23; P = .02), and the Early group showed better Kaplan-Meier curves (P = .02), higher 1-year survival rates (100% vs 50%, P = .03), and lower morbidity (days on IMV and length of stay in ICU and hospital). During the bridge to transplant, mortality increased steadily with time. Considering the overall outcome of the bridging program (25 patients), bridge duration adversely affected survival (HR, 1.06 per day; 95% CI, 1.01-1.11; P = .015) and 1-year survival (Early, 82% vs Late, 29%; P = .015). Morbidity indexes were lower in patients treated with NIV during the bridge. CONCLUSIONS: The duration of the ECMO bridge is a relevant cofactor in the mortality and morbidity of critically ill patients awaiting organ allocation. The NIV strategy was associated with a less complicated clinical course after LTX.
BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplant (LTX) is still being debated. METHODS: We performed a retrospective two-center analysis of the relationship between ECMO bridging duration and survival in 25 patients. Further survival analysis was obtained by dividing the patients according to waiting time on ECMO: up to 14 days (Early group) or longer (Late group). We also analyzed the impact of the ventilation strategy during ECMO bridging (ie, spontaneous breathing and noninvasive ventilation [NIV] or intubation and invasive mechanical ventilation [IMV]). RESULTS: Seventeen of 25 patients underwent a transplant (with a 76% 1-year survival), whereas eight patients died during bridging. In the 17 patients who underwent a transplant, mortality was positively related to waiting days until LTX (hazard ratio [HR], 1.12 per day; 95% CI, 1.02-1.23; P = .02), and the Early group showed better Kaplan-Meier curves (P = .02), higher 1-year survival rates (100% vs 50%, P = .03), and lower morbidity (days on IMV and length of stay in ICU and hospital). During the bridge to transplant, mortality increased steadily with time. Considering the overall outcome of the bridging program (25 patients), bridge duration adversely affected survival (HR, 1.06 per day; 95% CI, 1.01-1.11; P = .015) and 1-year survival (Early, 82% vs Late, 29%; P = .015). Morbidity indexes were lower in patients treated with NIV during the bridge. CONCLUSIONS: The duration of the ECMO bridge is a relevant cofactor in the mortality and morbidity of critically illpatients awaiting organ allocation. The NIV strategy was associated with a less complicated clinical course after LTX.
Authors: Sean M Wrenn; Ethan D Griswold; Franziska E Uhl; Juan J Uriarte; Heon E Park; Amy L Coffey; Jacob S Dearborn; Bethany A Ahlers; Bin Deng; Ying-Wai Lam; Dryver R Huston; Patrick C Lee; Darcy E Wagner; Daniel J Weiss Journal: PLoS One Date: 2018-06-27 Impact factor: 3.240
Authors: Marius M Hoeper; Raymond L Benza; Paul Corris; Marc de Perrot; Elie Fadel; Anne M Keogh; Christian Kühn; Laurent Savale; Walter Klepetko Journal: Eur Respir J Date: 2019-01-24 Impact factor: 16.671