Literature DB >> 23599019

Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality.

Ian Kelleher1, Helen Keeley, Paul Corcoran, Hugh Ramsay, Camilla Wasserman, Vladimir Carli, Marco Sarchiapone, Christina Hoven, Danuta Wasserman, Mary Cannon.   

Abstract

OBJECTIVE: Using longitudinal and prospective measures, the authors assessed the relationship between childhood trauma and psychotic experiences, addressing the following questions: 1) Does exposure to trauma predict incident psychotic experiences? 2) Does cessation of trauma predict cessation of psychotic experiences? 3) What is the direction of the relationship between childhood trauma and psychotic experiences?
METHOD: This was a nationally representative prospective cohort study of 1,112 school-based adolescents 13-16 years of age, assessed at baseline and at 3-month and 12-month follow-ups for childhood trauma (physical assault and bullying) and psychotic experiences.
RESULTS: A bidirectional relationship was observed between childhood trauma and psychosis, with trauma predicting psychotic experiences over time and vice versa. However, even after accounting for this bidirectional relationship with a number of strict adjustments (only newly incident psychotic experiences occurring over the course of the study following exposure to traumatic experiences were examined), trauma was strongly predictive of psychotic experiences. A dose-response relationship was observed between severity of bullying and risk for psychotic experiences. Moreover, cessation of trauma predicted cessation of psychotic experiences, with the incidence of psychotic experiences decreasing significantly in individuals whose exposure to trauma ceased over the course of the study.
CONCLUSIONS: After a series of conservative adjustments, the authors found that exposure to childhood trauma predicted newly incident psychotic experiences. The study also provides the first direct evidence that cessation of traumatic experiences leads to a reduced incidence of psychotic experiences.

Entities:  

Mesh:

Year:  2013        PMID: 23599019     DOI: 10.1176/appi.ajp.2012.12091169

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN: 0002-953X            Impact factor:   18.112


  90 in total

1.  Global Mental Health and Adolescent Anxiety: Kin, Care and Struggle in New Mexico.

Authors:  Janis H Jenkins; Annika Stone
Journal:  Cult Med Psychiatry       Date:  2017-12

Review 2.  Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms.

Authors:  Lauren E Gibson; Lauren B Alloy; Lauren M Ellman
Journal:  Clin Psychol Rev       Date:  2016-08-31

3.  Childhood Trauma Is Associated With Severity of Hallucinations and Delusions in Psychotic Disorders: A Systematic Review and Meta-Analysis.

Authors:  Thomas Bailey; Mario Alvarez-Jimenez; Ana M Garcia-Sanchez; Carol Hulbert; Emma Barlow; Sarah Bendall
Journal:  Schizophr Bull       Date:  2018-08-20       Impact factor: 9.306

4.  Posttraumatic Stress Disorder Symptoms and Social and Occupational Functioning of People With Schizophrenia.

Authors:  Lauren C Ng; Liana J Petruzzi; M Claire Greene; Kim T Mueser; Christina P C Borba; David C Henderson
Journal:  J Nerv Ment Dis       Date:  2016-08       Impact factor: 2.254

5.  Childhood abuse and neglect may induce deficits in cognitive precursors of psychosis in high-risk children.

Authors:  Nicolas Berthelot; Thomas Paccalet; Elsa Gilbert; Isabel Moreau; Chantal Mérette; Nathalie Gingras; Nancie Rouleau; Michel Maziade
Journal:  J Psychiatry Neurosci       Date:  2015-09       Impact factor: 6.186

Review 6.  Stress during critical periods of development and risk for schizophrenia.

Authors:  Felipe V Gomes; Xiyu Zhu; Anthony A Grace
Journal:  Schizophr Res       Date:  2019-01-30       Impact factor: 4.939

7.  The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries.

Authors:  J J McGrath; K A McLaughlin; S Saha; S Aguilar-Gaxiola; A Al-Hamzawi; J Alonso; R Bruffaerts; G de Girolamo; P de Jonge; O Esan; S Florescu; O Gureje; J M Haro; C Hu; E G Karam; V Kovess-Masfety; S Lee; J P Lepine; C C W Lim; M E Medina-Mora; Z Mneimneh; B E Pennell; M Piazza; J Posada-Villa; N Sampson; M C Viana; M Xavier; E J Bromet; K S Kendler; R C Kessler
Journal:  Psychol Med       Date:  2017-01-09       Impact factor: 7.723

8.  Whither the psychosis-neurosis borderline.

Authors:  Ian Kelleher; Mary Cannon
Journal:  Schizophr Bull       Date:  2014-01-16       Impact factor: 9.306

Review 9.  Bullying and psychosis: The impact of chronic traumatic stress on psychosis risk in 22q11.2 deletion syndrome - a uniquely vulnerable population.

Authors:  Danessa Mayo; Khalima A Bolden; Tony J Simon; Tara A Niendam
Journal:  J Psychiatr Res       Date:  2019-04-15       Impact factor: 4.791

10.  Social Adversity and Psychosis: The Mediating Role of Cognitive Vulnerability.

Authors:  Edo S Jaya; Leonie Ascone; Tania M Lincoln
Journal:  Schizophr Bull       Date:  2017-05-01       Impact factor: 9.306

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.