Literature DB >> 23598077

pH-sensitive poly(glutamic acid) grafted mesoporous silica nanoparticles for drug delivery.

Jin Zheng1, Xuejiao Tian, Yangfei Sun, Daru Lu, Wuli Yang.   

Abstract

pH-sensitive poly(L-glutamic acid) grafted mesoporous silica nanoparticles (MSN-PLGA) were prepared by the surface-initiated N-carboxyanhydride polymerization method. The resultant MSN-PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and significantly higher drug release rates. The cumulative release of doxorubicin hydrochloride (DOX) from DOX-loaded MSN-PLGA (DOX@MSN-PLGA) was pH-dependent and the release rate was much higher at pH 5.5 than that at pH 7.4. The cytotoxicity results indicated that the blank MSN-PLGA was biocompatible and the DOX@MSN-PLGA had potent in vitro cytotoxicity effect similar to free DOX. Overall, these results demonstrate that MSN-PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy.
Copyright © 2013 Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23598077     DOI： 10.1016/j.ijpharm.2013.04.014

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


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