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Literature DB >> 23597067

Novel double [3 + 2 + 1] heteroannulation for forming unprecedented dipyrazolo-fused 2,6-naphthyridines.

Wei Fan¹, Qin Ye, Hai-Wei Xu, Bo Jiang, Shu-Liang Wang, Shu-Jiang Tu.

Abstract

A novel four-component strategy for the efficient synthesis of unprecedented dipyrazolo-fused 2,6-naphthyridines through a double [3 + 2+1] heteroannulation has been described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble tetra-heterocyclic scaffolds.

Entities: Chemical Disease

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Year: 2013 PMID： 23597067 DOI： 10.1021/ol4008266

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

8 in total

1. Cascade bicyclization of triethylammonium thiolates with hydrazines: efficient access to pyrazolo[3,4-c]quinolines.

Authors: Wei Fan; Yan-Rong Li; Bo Jiang; Guigen Li
Journal: Org Biomol Chem Date: 2016-09-26 Impact factor: 3.876

2. Four-component strategy for selective synthesis of azepino[5,4,3-cd]indoles and pyrazolo[3,4-b]pyridines.

Authors: Bo Jiang; Qin Ye; Wei Fan; Shu-Liang Wang; Shu-Jiang Tu; Guigen Li
Journal: Chem Commun (Camb) Date: 2014-06-11 Impact factor: 6.222

3. Metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization: stereospecific construction with concomitant functionalization of indolizin-5(1H)-one.

Authors: Tuan-Jie Li; Zhong-Qiu Liu; Hong-Mei Yin; Chang-Sheng Yao; Bo Jiang; Xiang-Shan Wang; Shu-Jiang Tu; Xiu-Ling Li; Guigen Li
Journal: J Org Chem Date: 2013-11-07 Impact factor: 4.354

8. Domino reaction of arylglyoxals with pyrazol-5-amines: selective access to pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles.

Authors: Bo Jiang; Wei Fan; Mu-Yan Sun; Qin Ye; Shu-Liang Wang; Shu-Jiang Tu; Guigen Li
Journal: J Org Chem Date: 2014-05-22 Impact factor: 4.354

8 in total

Novel double [3 + 2 + 1] heteroannulation for forming unprecedented dipyrazolo-fused 2,6-naphthyridines.

1. Cascade bicyclization of triethylammonium thiolates with hydrazines: efficient access to pyrazolo[3,4-c]quinolines.

2. Four-component strategy for selective synthesis of azepino[5,4,3-cd]indoles and pyrazolo[3,4-b]pyridines.

3. Metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization: stereospecific construction with concomitant functionalization of indolizin-5(1H)-one.

4. New Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines.

5. Four-component bicyclization approaches to skeletally diverse pyrazolo[3,4-b]pyridine derivatives.

6. Synthesis of isocoumarins with different substituted patterns via Passerini-aldol sequence.

7. Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles.

8. Domino reaction of arylglyoxals with pyrazol-5-amines: selective access to pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles.