Literature DB >> 23595956

Total synthesis of an immunomodulatory phosphoglycolipid from thermophilic bacteria.

Hong-Jyune Lin1, Avijit Kumar Adak, L Vijaya Raghava Reddy, Shih-Hsiung Wu, Chun-Cheng Lin.   

Abstract

A method for the stereocontrolled synthesis of a bacterial phosphoglycolipid (PGL1) isolated from thermophilic bacteria is described. The key features of the synthesis include a highly α-selective glycosylation reaction between a trichloroacetimidate donor and a D-lyxose-derived primary alcohol acceptor and the late-stage incorporation of the phospholipid.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID: 23595956     DOI: 10.1002/chem.201204550

Source DB:  PubMed          Journal:  Chemistry        ISSN: 0947-6539            Impact factor:   5.236


  1 in total

1.  Synthesis and structural characterization of three unique Helicobacter pylori α-cholesteryl phosphatidyl glucosides.

Authors:  Huy Q Nguyen; Ryan A Davis; Jacquelyn Gervay-Hague
Journal:  Angew Chem Int Ed Engl       Date:  2014-09-04       Impact factor: 15.336

  1 in total

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