BACKGROUND: Open radical cystectomy (ORC) is the gold standard of treatment for muscle-invasive bladder cancer. Laparoscopic radical cystectomy (LRC) has emerged to provide an alternative. METHODS: Between 2006 and 2012, 155 patients who underwent LRC or ORC were compared (mean follow-up 53 months). RESULTS: The ORC group had shorter operative times (p < 0.0001), more blood loss (p < 0.00001), more transfusion requirement (p < 0.00001), longer postoperative length of hospital stay (p < 0.00001) and more morphine requirement (p = 0.02). No difference was found regarding lymph node yield (p = 0.07), positive margins (p = 0.11), cystectomy pathology results (p > 0.05) and positive lymph nodes (p = 0.02). The ORC group had less intraoperative complications (p = 0.03). No difference was found between the two groups regarding 5-year overall survival (p = 0.93), cancer-specific survival (p = 0.7) and recurrence-free survival (p = 0.62). CONCLUSION: LRC can be considered as an alternative to ORC with good operative and postoperative results in addition to comparable 5-year survival results.
BACKGROUND: Open radical cystectomy (ORC) is the gold standard of treatment for muscle-invasive bladder cancer. Laparoscopic radical cystectomy (LRC) has emerged to provide an alternative. METHODS: Between 2006 and 2012, 155 patients who underwent LRC or ORC were compared (mean follow-up 53 months). RESULTS: The ORC group had shorter operative times (p < 0.0001), more blood loss (p < 0.00001), more transfusion requirement (p < 0.00001), longer postoperative length of hospital stay (p < 0.00001) and more morphine requirement (p = 0.02). No difference was found regarding lymph node yield (p = 0.07), positive margins (p = 0.11), cystectomy pathology results (p > 0.05) and positive lymph nodes (p = 0.02). The ORC group had less intraoperative complications (p = 0.03). No difference was found between the two groups regarding 5-year overall survival (p = 0.93), cancer-specific survival (p = 0.7) and recurrence-free survival (p = 0.62). CONCLUSION: LRC can be considered as an alternative to ORC with good operative and postoperative results in addition to comparable 5-year survival results.
Authors: Antonio Luigi Pastore; Giovanni Palleschi; Luigi Silvestri; Giuseppe Cavallaro; Mario Rizzello; Gianfranco Silecchia; Cosimo de Nunzio; Samer Fathi Al-Rawashdah; Vincenzo Petrozza; Antonio Carbone Journal: BMC Urol Date: 2014-11-18 Impact factor: 2.264
Authors: Lin Dong; Feng Xiaoli; Lu Ya; Wu Dan; Hu Jingwen; Liu Xun; Chen Shujin; Zhou Zhijun; Zhang Tian; Luo Hao; Yi Chuanlang; Chen Guangrong; Wang Xiaodong; Luo Gewen; Zhang Yichi; Cao Pei; Liu Yang; Wang Youliang Journal: Medicine (Baltimore) Date: 2022-08-26 Impact factor: 1.817