Z Zhang1, X Xu, H Ni, N Jin. 1. Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China. zh_zhang184 @ hotmail.com
Abstract
PURPOSE: Serum cystatin C (sCyC) has long been known as a reliable biomarker of renal injury. However, it remains to be tested whether sCyC is a reliable biomarker to predict renal recovery after continuous renal replacement therapy (CRRT). METHODS: A retrospective analysis of patients admitted to a tertiary 18-bed intensive care unit from January 2008 to December 2011 was performed. Univariate and multivariate regression analyses were performed to test the independent predictors of renal recovery. The diagnostic value of sCyC in predicting renal recovery was assessed using a receiver operating characteristic curve (ROC). RESULTS: Older age and higher sCyC were independent risk factors of renal nonrecovery (OR: 1.40 and 4.76, respectively). The area under the ROC of sCyC to predict renal recovery was 0.87 (95% CI: 0.82-0.92), with a sensitivity and specificity of 80.5% and 83.5% at the cutoff of 2.98 mg/l. CONCLUSION: A high sCyC level at the initiation of CRRT is associated with poor renal outcome.
PURPOSE: Serum cystatin C (sCyC) has long been known as a reliable biomarker of renal injury. However, it remains to be tested whether sCyC is a reliable biomarker to predict renal recovery after continuous renal replacement therapy (CRRT). METHODS: A retrospective analysis of patients admitted to a tertiary 18-bed intensive care unit from January 2008 to December 2011 was performed. Univariate and multivariate regression analyses were performed to test the independent predictors of renal recovery. The diagnostic value of sCyC in predicting renal recovery was assessed using a receiver operating characteristic curve (ROC). RESULTS: Older age and higher sCyC were independent risk factors of renal nonrecovery (OR: 1.40 and 4.76, respectively). The area under the ROC of sCyC to predict renal recovery was 0.87 (95% CI: 0.82-0.92), with a sensitivity and specificity of 80.5% and 83.5% at the cutoff of 2.98 mg/l. CONCLUSION: A high sCyC level at the initiation of CRRT is associated with poor renal outcome.
Authors: Abdalrhman Al Saadon; Riley Katulka; Meghan Sebastianski; Robin Featherstone; Ben Vandermeer; R T Noel Gibney; Oleksa G Rewa; Sean M Bagshaw Journal: BMJ Open Date: 2018-11-25 Impact factor: 2.692
Authors: Riley Jeremy Katulka; Abdalrhman Al Saadon; Meghan Sebastianski; Robin Featherstone; Ben Vandermeer; Samuel A Silver; R T Noel Gibney; Sean M Bagshaw; Oleksa G Rewa Journal: Crit Care Date: 2020-02-13 Impact factor: 9.097
Authors: Kevin Pilarczyk; Michaela Edayadiyil-Dudasova; Daniel Wendt; Ender Demircioglu; Jaroslav Benedik; Daniel Sebastian Dohle; Heinz Jakob; Fabian Dusse Journal: Ann Intensive Care Date: 2015-12-15 Impact factor: 6.925