M Wang1, Z Zhang, J Zhu, W Sheng, P Lian, F Liu, S Cai, Y Xu. 1. Department of Colorectal Surgery, Cancer Hospital, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Abstract
AIM: Anorectal melanoma is a rare neoplasm with poor prognosis. The aim of this study was to investigate what clinicopathological factors predict lymph node metastases and to investigate their association with survival. METHOD: Patients undergoing surgery with curative intent for primary anorectal melanoma in Fudan University Shanghai Cancer Center between 1989 and 2011 were studied retrospectively. The associations between clinicopathological factors and lymph node metastases and prognosis were determined. RESULTS: Forty-three patients underwent a potentially curative resection with a median follow-up of 20 months; the 5-year overall survival rate was 29.6% with median overall survival of 28 months. Tumour diameter > 3 cm was associated with mesorectal and mesenteric lymph node metastases (P = 0.013). Perineural invasion (hazard ratio 5.683; 95% CI 1.978-16.328; P = 0.001) was the only factor that independently predicted survival. CONCLUSION: Tumour diameter was associated with mesorectal and mesenteric lymph node metastases; therefore, wide local excision may not be appropriate for surgery with curative intent for patients with a tumour diameter ≥ 3 cm. Perineural invasion was an important prognostic factor for anorectal melanoma. Colorectal Disease
AIM: Anorectal melanoma is a rare neoplasm with poor prognosis. The aim of this study was to investigate what clinicopathological factors predict lymph node metastases and to investigate their association with survival. METHOD:Patients undergoing surgery with curative intent for primary anorectal melanoma in Fudan University Shanghai Cancer Center between 1989 and 2011 were studied retrospectively. The associations between clinicopathological factors and lymph node metastases and prognosis were determined. RESULTS: Forty-three patients underwent a potentially curative resection with a median follow-up of 20 months; the 5-year overall survival rate was 29.6% with median overall survival of 28 months. Tumour diameter > 3 cm was associated with mesorectal and mesenteric lymph node metastases (P = 0.013). Perineural invasion (hazard ratio 5.683; 95% CI 1.978-16.328; P = 0.001) was the only factor that independently predicted survival. CONCLUSION:Tumour diameter was associated with mesorectal and mesenteric lymph node metastases; therefore, wide local excision may not be appropriate for surgery with curative intent for patients with a tumour diameter ≥ 3 cm. Perineural invasion was an important prognostic factor for anorectal melanoma. Colorectal Disease
Authors: David D B Bates; Maria Clara Fernandes de Paula; Natally Horvat; Shannon Sheedy; Chandana Lall; Zahra Kassam; Perry Pickhardt; Neeraj Lalwani; Dhakshinamoorthy Ganeshan; Iva Petkovska Journal: Abdom Radiol (NY) Date: 2019-11
Authors: Brooke E Rosenbaum; Christine N Schafer; Sung Won Han; Iman Osman; Hua Zhong; Nooshin Brinster Journal: Mod Pathol Date: 2017-07-21 Impact factor: 7.842
Authors: Claudius Falch; Sven Mueller; Andreas Kirschniak; Manuel Braun; Alfred Koenigsrainer; Bernhard Klumpp Journal: World J Surg Oncol Date: 2016-07-15 Impact factor: 2.754
Authors: Esther Jutten; Schelto Kruijff; Anne Brecht Francken; Martijn F Lutke Holzik; Barbara L van Leeuwen; Henderik L van Westreenen; Kevin P Wevers Journal: BJS Open Date: 2021-11-09