Literature DB >> 23594098

Copper-mediated, palladium-catalyzed cross-coupling of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate.

Xiaodong Han1, Zhizhou Yue, Xiaofei Zhang, Qian He, Chunhao Yang.   

Abstract

The palladium-catalyzed cross-coupling reaction of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate in the presence of a copper mediator is reported. Under optimized conditions, all reactions worked well and provided difluoro-containing products in moderate to excellent yields.

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Year:  2013        PMID： 23594098     DOI： 10.1021/jo400412k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Development of Conjugate Addition of Lithium Dialkylcuprates to Thiochromones: Synthesis of 2-Alkylthiochroman-4-ones and Additional Synthetic Applications.

Authors:  Shekinah A Bass; Dynasty M Parker; Tania J Bellinger; Aireal S Eaton; Angelica S Dibble; Kaata L Koroma; Sylvia A Sekyi; David A Pollard; Fenghai Guo
Journal:  Molecules       Date:  2018-07-15       Impact factor: 4.411

2.  Conjugate Addition of Grignard Reagents to Thiochromones Catalyzed by Copper Salts: A Unified Approach to Both 2-Alkylthiochroman-4-One and Thioflavanone.

Authors:  Tania J Bellinger; Teavian Harvin; Ti'Bran Pickens-Flynn; Nataleigh Austin; Samuel H Whitaker; Mai Ling C Tang Yuk Tutein; Dabria T Hukins; Nichele Deese; Fenghai Guo
Journal:  Molecules       Date:  2020-05-01       Impact factor: 4.411
  2 in total

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