BACKGROUND: Although earlier studies demonstrated endothelial dysfunction and systemic inflammation in patients with microvascular angina (MVA), the correlations between flow-mediated dilation (FMD), high-sensitivity C-reactive protein (hsCRP) levels and Duke treadmill score (DTS), a comprehensive index representing the severity of ischemia, have not been elucidated in this setting. OBJECTIVE: To explore the possible relationships among brachial FMD, serum hsCRP levels and DTS in MVA patients. METHODS AND RESULTS: A total of 89 subjects with chest pain and a normal coronary angiogram were studied. The exercise treadmill test (ETT) was performed using the Bruce protocol for calculating the DTS. Brachial FMD and serum hsCRP levels were measured. The mean (± SD) brachial FMD was 5.45±2.24% in the group with positive ETT and 8.19±2.78% in the group with a negative ETT (P<0.001). Mean serum hsCRP levels were significantly higher in the group with positive ETT than in the group with negative ETT (4.93±1.63 mg/L versus 3.41±1.65 mg/L; P<0.001). Brachial FMD and serum hsCRP levels showed significant differences among the three groups according to DTS risk stratification. The DTS was positively correlated with FMD (r=0.532; P<0.001) and negatively correlated with hsCRP level (r= 0.461; P<0.001). CONCLUSIONS: Brachial FMD and serum hsCRP levels may be associated with DTS in patients with MVA.
BACKGROUND: Although earlier studies demonstrated endothelial dysfunction and systemic inflammation in patients with microvascular angina (MVA), the correlations between flow-mediated dilation (FMD), high-sensitivity C-reactive protein (hsCRP) levels and Duke treadmill score (DTS), a comprehensive index representing the severity of ischemia, have not been elucidated in this setting. OBJECTIVE: To explore the possible relationships among brachial FMD, serum hsCRP levels and DTS in MVApatients. METHODS AND RESULTS: A total of 89 subjects with chest pain and a normal coronary angiogram were studied. The exercise treadmill test (ETT) was performed using the Bruce protocol for calculating the DTS. Brachial FMD and serum hsCRP levels were measured. The mean (± SD) brachial FMD was 5.45±2.24% in the group with positive ETT and 8.19±2.78% in the group with a negative ETT (P<0.001). Mean serum hsCRP levels were significantly higher in the group with positive ETT than in the group with negative ETT (4.93±1.63 mg/L versus 3.41±1.65 mg/L; P<0.001). Brachial FMD and serum hsCRP levels showed significant differences among the three groups according to DTS risk stratification. The DTS was positively correlated with FMD (r=0.532; P<0.001) and negatively correlated with hsCRP level (r= 0.461; P<0.001). CONCLUSIONS:Brachial FMD and serum hsCRP levels may be associated with DTS in patients with MVA.
Authors: P Tondi; A Santoliquido; A Di Giorgio; A Sestito; G A Sgueglia; R Flore; G Careri; G Pinnacchio; G A Lanza; F Crea Journal: Eur Rev Med Pharmacol Sci Date: 2011-09 Impact factor: 3.507
Authors: G A Lanza; T F Lüscher; V Pasceri; S G Shaw; A Buffon; A S Montenero; F Crea; A Maseri Journal: Am J Cardiol Date: 1999-11-15 Impact factor: 2.778
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Authors: D B Mark; L Shaw; F E Harrell; M A Hlatky; K L Lee; J R Bengtson; C B McCants; R M Califf; D B Pryor Journal: N Engl J Med Date: 1991-09-19 Impact factor: 91.245
Authors: Gregory G Johnson; Wyatt W Decker; Joseph K Lobl; Dennis A Laudon; Jennifer J Hess; Christine M Lohse; Amy L Weaver; Deepi G Goyal; Peter A Smars; Guy S Reeder Journal: Int J Emerg Med Date: 2008-06-03