OBJECTIVE: To evaluate left ventricular function in young adults with mitral valve prolapse (MVP) without significant mitral regurgitation using two-dimensional strain imaging. METHODS AND RESULTS: A total of 58 asymptomatic young subjects (mean [± SD] age 19.7±1.6 years; 72% male) with MVP were compared with 60 sex- and age-matched healthy subjects. MVP was diagnosed by billowing one or both mitral leaflets >2 mm above the mitral annulus in the long-axis parasternal view. Longitudinal, radial and circumferential strain and strain rate were determined using speckle tracking with a grey-scale frame rate of 50 fps to 85 fps. There were no significant differences in the global systolic left ventricular function of the subjects with MVP compared with the control group. In the MVP group, most of the global myocardial systolic deformation indexes were not reduced. Only the global circumferential strain showed a decrease in the prolapse subjects. Regional, longitudinal, circumferential and radial strain and strain rate were decreased only in septal segments. A decrease in the rotation of the same septal segments at the basal level was also observed. CONCLUSION: Regional septal myocardial deformation indexes decrease in subjects with MVP. These changes may be the first sign indicating the deterioration of left ventricular systolic function as well as the existence of primary cardiomyopathy in asymptomatic young subjects with MVP.
OBJECTIVE: To evaluate left ventricular function in young adults with mitral valve prolapse (MVP) without significant mitral regurgitation using two-dimensional strain imaging. METHODS AND RESULTS: A total of 58 asymptomatic young subjects (mean [± SD] age 19.7±1.6 years; 72% male) with MVP were compared with 60 sex- and age-matched healthy subjects. MVP was diagnosed by billowing one or both mitral leaflets >2 mm above the mitral annulus in the long-axis parasternal view. Longitudinal, radial and circumferential strain and strain rate were determined using speckle tracking with a grey-scale frame rate of 50 fps to 85 fps. There were no significant differences in the global systolic left ventricular function of the subjects with MVP compared with the control group. In the MVP group, most of the global myocardial systolic deformation indexes were not reduced. Only the global circumferential strain showed a decrease in the prolapse subjects. Regional, longitudinal, circumferential and radial strain and strain rate were decreased only in septal segments. A decrease in the rotation of the same septal segments at the basal level was also observed. CONCLUSION: Regional septal myocardial deformation indexes decrease in subjects with MVP. These changes may be the first sign indicating the deterioration of left ventricular systolic function as well as the existence of primary cardiomyopathy in asymptomatic young subjects with MVP.
Authors: Robert O Bonow; Blase A Carabello; Kanu Chatterjee; Antonio C de Leon; David P Faxon; Michael D Freed; William H Gaasch; Bruce Whitney Lytle; Rick A Nishimura; Patrick T O'Gara; Robert A O'Rourke; Catherine M Otto; Pravin M Shah; Jack S Shanewise; Sidney C Smith; Alice K Jacobs; Cynthia D Adams; Jeffrey L Anderson; Elliott M Antman; Valentin Fuster; Jonathan L Halperin; Loren F Hiratzka; Sharon A Hunt; Bruce W Lytle; Rick Nishimura; Richard L Page; Barbara Riegel Journal: J Am Coll Cardiol Date: 2006-08-01 Impact factor: 24.094
Authors: Patrizio Lancellotti; Bernard Cosyns; Dimitris Zacharakis; Emilio Attena; Guy Van Camp; Olivier Gach; Marc Radermecker; Luc A Piérard Journal: J Am Soc Echocardiogr Date: 2008-12 Impact factor: 5.251
Authors: David Oxborough; Alan M Batterham; Rob Shave; Nigel Artis; Karen M Birch; Greg Whyte; Philip N Ainslie; Keith P George Journal: Eur J Echocardiogr Date: 2009-04-09
Authors: C Delhomme; D Casset-Senon; D Babuty; J C Charniot; L Fauchier; J P Fauchier; L Philippe; P Cosnay Journal: Arch Mal Coeur Vaiss Date: 1996-09
Authors: D Casset-Senon; D Babuty; L Philippe; L Fauchier; V Eder; J P Fauchier; J M Pottier; C Delhomme; P Cosnay Journal: J Nucl Cardiol Date: 2000 Sep-Oct Impact factor: 5.952
Authors: Havard Dalen; Anders Thorstensen; Svein A Aase; Charlotte B Ingul; Hans Torp; Lars J Vatten; Asbjorn Stoylen Journal: Eur J Echocardiogr Date: 2009-11-28
Authors: Philip T Levy; Aliza Machefsky; Aura A Sanchez; Meghna D Patel; Sarah Rogal; Susan Fowler; Lauren Yaeger; Angela Hardi; Mark R Holland; Aaron Hamvas; Gautam K Singh Journal: J Am Soc Echocardiogr Date: 2015-12-30 Impact factor: 5.251
Authors: Hersh S Maniar; Beckah D Brady; Urvi Lee; Brian P Cupps; Julia Kar; Kathleen M Wallace; Michael K Pasque Journal: J Thorac Cardiovasc Surg Date: 2014-07-19 Impact factor: 5.209
Authors: Andrea Sonaglioni; Gian Luigi Nicolosi; Michele Lombardo; Gian Franco Gensini; Giuseppe Ambrosio Journal: Int J Cardiovasc Imaging Date: 2020-10-30 Impact factor: 2.357