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Literature DB >> 23592388

Regioselective arene halogenation using the FAD-dependent halogenase RebH.

James T Payne¹, Mary C Andorfer, Jared C Lewis.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23592388 PMCID： PMC3824154 DOI： 10.1002/anie.201300762

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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24 in total

1. The biosynthesis of indolocarbazoles in a heterologous E. coli host.

Authors: Chang-Gu Hyun; Tsion Bililign; Jianchun Liao; Jon S Thorson
Journal: Chembiochem Date: 2003-01-03 Impact factor: 3.164

Review 2. Enhancement of soluble protein expression through the use of fusion tags.

Authors: Dominic Esposito; Deb K Chatterjee
Journal: Curr Opin Biotechnol Date: 2006-06-15 Impact factor: 9.740

Review 3. Nature's inventory of halogenation catalysts: oxidative strategies predominate.

Authors: Frédéric H Vaillancourt; Ellen Yeh; David A Vosburg; Sylvie Garneau-Tsodikova; Christopher T Walsh
Journal: Chem Rev Date: 2006-08 Impact factor: 60.622

4. The structure of flavin-dependent tryptophan 7-halogenase RebH.

Authors: Eduard Bitto; Yu Huang; Craig A Bingman; Shanteri Singh; Jon S Thorson; George N Phillips
Journal: Proteins Date: 2008-01-01

Review 5. The unique role of halogen substituents in the design of modern agrochemicals.

Authors: Peter Jeschke
Journal: Pest Manag Sci Date: 2010-01 Impact factor: 4.845

6. Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor.

Authors: Weslee S Glenn; Ezekiel Nims; Sarah E O'Connor
Journal: J Am Chem Soc Date: 2011-11-11 Impact factor: 15.419

Review 7. Cofactor regeneration at the lab scale.

Authors: R Wichmann; D Vasic-Racki
Journal: Adv Biochem Eng Biotechnol Date: 2005 Impact factor: 2.635

8. Combinatorial biosynthesis of antitumor indolocarbazole compounds.

Authors: César Sánchez; Lili Zhu; Alfredo F Braña; Aaroa P Salas; Jürgen Rohr; Carmen Méndez; José A Salas
Journal: Proc Natl Acad Sci U S A Date: 2004-12-29 Impact factor: 11.205

9. Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly.

Authors: John R Heemstra; Christopher T Walsh
Journal: J Am Chem Soc Date: 2008-10-02 Impact factor: 15.419

10. Integrating carbon-halogen bond formation into medicinal plant metabolism.

Authors: Weerawat Runguphan; Xudong Qu; Sarah E O'Connor
Journal: Nature Date: 2010-11-03 Impact factor: 49.962

38 in total

1. Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

Authors: Amy E Fraley; Marc Garcia-Borràs; Ashootosh Tripathi; Dheeraj Khare; Eduardo V Mercado-Marin; Hong Tran; Qingyun Dan; Gabrielle P Webb; Katharine R Watts; Phillip Crews; Richmond Sarpong; Robert M Williams; Janet L Smith; K N Houk; David H Sherman
Journal: J Am Chem Soc Date: 2017-08-21 Impact factor: 15.419

Regioselective arene halogenation using the FAD-dependent halogenase RebH.

1. The biosynthesis of indolocarbazoles in a heterologous E. coli host.

Review 2. Enhancement of soluble protein expression through the use of fusion tags.

Review 3. Nature's inventory of halogenation catalysts: oxidative strategies predominate.

4. The structure of flavin-dependent tryptophan 7-halogenase RebH.

Review 5. The unique role of halogen substituents in the design of modern agrochemicals.

6. Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor.

Review 7. Cofactor regeneration at the lab scale.

8. Combinatorial biosynthesis of antitumor indolocarbazole compounds.

9. Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly.

10. Integrating carbon-halogen bond formation into medicinal plant metabolism.

1. Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

Review 2. Halogenase engineering and its utility in medicinal chemistry.

3. Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization.

4. Improving the stability and catalyst lifetime of the halogenase RebH by directed evolution.

5. Catalyst-Controlled Site-Selective Bond Activation.

6. Structure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal.

Review 7. Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.

8. A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering.

9. Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I.

Review 10. Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis.