BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with an independent increased risk of lung carcinogenesis. The benefit of chemotherapy for extensive-stage small-cell lung cancer (ED-SCLC) in cases of IPF remains unknown. This study was conducted to elucidate the efficacy of chemotherapy for ED-SCLC in patients with IPF. METHODS: This was a retrospective observational study of ED-SCLC patients with IPF (all with distant metastasis) who received systemic chemotherapy. The response rate, toxicity, overall survival, and progression-free survival (PFS) were investigated. RESULTS: Eleven patients treated with chemotherapy between January 2005 and December 2011 were the subjects of this study. The overall response rate with the 1st regimen was 63.6 %. The median overall survival was 7.0 months, and the median PFS was 4.7 months. CONCLUSION: Our results suggest that ED-SCLC patients with IPF may benefit from chemotherapy. A prospective study will be needed to confirm this in the future.
BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is associated with an independent increased risk of lung carcinogenesis. The benefit of chemotherapy for extensive-stage small-cell lung cancer (ED-SCLC) in cases of IPF remains unknown. This study was conducted to elucidate the efficacy of chemotherapy for ED-SCLC in patients with IPF. METHODS: This was a retrospective observational study of ED-SCLCpatients with IPF (all with distant metastasis) who received systemic chemotherapy. The response rate, toxicity, overall survival, and progression-free survival (PFS) were investigated. RESULTS: Eleven patients treated with chemotherapy between January 2005 and December 2011 were the subjects of this study. The overall response rate with the 1st regimen was 63.6 %. The median overall survival was 7.0 months, and the median PFS was 4.7 months. CONCLUSION: Our results suggest that ED-SCLCpatients with IPF may benefit from chemotherapy. A prospective study will be needed to confirm this in the future.
Authors: T Johkoh; N L Müller; Y Cartier; P V Kavanagh; T E Hartman; M Akira; K Ichikado; M Ando; H Nakamura Journal: Radiology Date: 1999-05 Impact factor: 11.105
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Authors: Mark A Socinski; Egbert F Smit; Paul Lorigan; Kartik Konduri; Martin Reck; Aleksandra Szczesna; Johnetta Blakely; Piotr Serwatowski; Nina A Karaseva; Tudor Ciuleanu; Jacek Jassem; Mircea Dediu; Shengyan Hong; Carla Visseren-Grul; Axel-Rainer Hanauske; Coleman K Obasaju; Susan C Guba; Nick Thatcher Journal: J Clin Oncol Date: 2009-08-31 Impact factor: 44.544
Authors: Myung Jin Song; Sung Yoon Lim; Jong Sun Park; Ho Il Yoon; Jae-Ho Lee; Song Yee Kim; Ji Ye Jung; Young Ae Kang; Moo Suk Park; Young Sam Kim; Joon Chang; Sang Hoon Lee; Choon-Taek Lee Journal: J Oncol Date: 2019-05-02 Impact factor: 4.375