BACKGROUND: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. RESULTS: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. CONCLUSIONS: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls.
BACKGROUND: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. RESULTS: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. CONCLUSIONS: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls.
Authors: Aaron X Sun; Ricardo Londono; Megan L Hudnall; Rocky S Tuan; Thomas P Lozito Journal: Proc Natl Acad Sci U S A Date: 2018-08-13 Impact factor: 11.205
Authors: Nathaniel Enos; Hidehito Takenaka; Sarah Scott; Hai V N Salfity; Maia Kirk; Margaret W Egar; Deborah A Sarria; Denise Slayback-Barry; Teri Belecky-Adams; Ellen A G Chernoff Journal: Front Immunol Date: 2019-11-01 Impact factor: 7.561