| Literature DB >> 23591566 |
María Ángeles Medrano1, Amparo Álvarez-Valdés, Josefina Perles, Julio Lloret-Fillol, Sandra Muñoz-Galván, Amancio Carnero, Carmen Navarro-Ranninger, Adoración G Quiroga.
Abstract
The synthesis, characterization and cytotoxicity studies of two novel platinum(IV) complexes, trans-PtCl4(dma)(PPh3), 1, and trans-PtCl4(ipa)(PPh3), 2, where dma is dimethylamine and ipa is isopropylamine, have been carried out. Both complexes contain aliphatic amines trans to phosphane ligands as a good alternative to take advantage of the phosphane group lipophilicity and the stability of platinum(IV) to obtain more effective drugs. Moreover, the complexes are stable in solution and such stability allowed their antitumoral action and DNA interaction to be checked and proved.Entities:
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Year: 2013 PMID： 23591566 DOI： 10.1039/c3cc38416k
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222