Parental depression confers greater prospective depression risk to females than males in emerging adulthood.

Females are at greater risk of depression than males, a pattern arising in adolescence and continuing in adulthood. One hypothesis is that major risk factors operate more robustly for females. We tested whether parental depression history imposes greater prospective depression risk for female emerging adults in a large community sample (ages 18-19, N = 637). Utilizing linear mixed regressions to model symptom changes over 2 years, we found the predictive utility of parental depression varied by gender. Females had higher depression symptoms overall, and those with parental depression remained at high levels throughout the adulthood transition, compared to at-risk males whose elevated symptoms decreased. This effect was specific to offspring depression (versus anxiety) and was found only for parental depression (versus other disorders). Female emerging adults with a parental depression history are at increased risk for future depression symptom elevations, which may partially explain their increased risk for depressive disorders in adulthood.