Literature DB >> 23589735

Life-threatening rhabdomyolysis following the interaction of two commonly prescribed medications.

Alireza Fallah1, Maitri Deep, David Smallwood, Peter Hughes.   

Abstract

We report an interaction between erythromycin and simvastatin resulting in life-threatening rhabdomyolysis in an elderly patient. Drugs that inhibit CYP3A4 enzyme can cause elevated serum levels of statins which amplifies the risk of statin-induced rhabdomyolysis. Physicians should be aware of potential drug interactions of statins, which are widely used in the community.

Entities:  

Keywords:  Drug interaction; Macrolides; Rhabdomyolysis; Statins

Year:  2013        PMID： 23589735      PMCID： PMC3626026          DOI： 10.4066/AMJ.2013.1616

Source DB:  PubMed          Journal:  Australas Med J        ISSN： 1836-1935


  5 in total

Review 1.  Clinical perspectives of statin-induced rhabdomyolysis.

Authors:  Kenneth A Antons; Craig D Williams; Steven K Baker; Paul S Phillips
Journal:  Am J Med       Date:  2006-05       Impact factor: 4.965

2.  Co-medication of statins and CYP3A4 inhibitors before and after introduction of new reimbursement policy.

Authors:  Helene M Devold; Espen Molden; Svetlana Skurtveit; Kari Furu
Journal:  Br J Clin Pharmacol       Date:  2009-02-09       Impact factor: 4.335

3.  Rhabdomyolysis following clarithromycin monotherapy.

Authors:  Zachary Z Brener; Ilya Bilik; Boris Khorets; James F Winchester; Michael Bergman
Journal:  Am J Med Sci       Date:  2009-07       Impact factor: 2.378

4.  Drug-induced rhabdomyolysis after concomitant use of clarithromycin, atorvastatin, and lopinavir/ritonavir in a patient with HIV.

Authors:  Jinell B Mah Ming; M John Gill
Journal:  AIDS Patient Care STDS       Date:  2003-05       Impact factor: 5.078

5.  Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.

Authors:  Espen Molden; Eva Skovlund; Pia Braathen
Journal:  Drug Saf       Date:  2008       Impact factor: 5.606
  5 in total
  4 in total

Review 1.  Genetics and personalized medicine--a role in statin therapy?

Authors:  Jaideep Patel; Thura Abd; Roger S Blumenthal; Khurram Nasir; H Robert Superko
Journal:  Curr Atheroscler Rep       Date:  2014-01       Impact factor: 5.113

2.  Statins for asthma.

Authors:  Cho Naing; Han Ni
Journal:  Cochrane Database Syst Rev       Date:  2020-07-15

3.  The clinical significance of statins-macrolides interaction: comprehensive review of in vivo studies, case reports, and population studies.

Authors:  Abdallah Abu Mellal; Nadia Hussain; Amira Sa Said
Journal:  Ther Clin Risk Manag       Date:  2019-07-23       Impact factor: 2.423

Review 4.  Statin-Induced Myopathy: Translational Studies from Preclinical to Clinical Evidence.

Authors:  Giulia Maria Camerino; Nancy Tarantino; Ileana Canfora; Michela De Bellis; Olimpia Musumeci; Sabata Pierno
Journal:  Int J Mol Sci       Date:  2021-02-19       Impact factor: 5.923
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.