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Literature DB >> 23589020

Thymic epithelial cell development and differentiation: cellular and molecular regulation.

Lina Sun¹, Haiying Luo, Hongran Li, Yong Zhao.

Abstract

Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.

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Year: 2013 PMID： 23589020 PMCID： PMC4883051 DOI： 10.1007/s13238-013-3014-0

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

130 in total

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Journal: Blood Date: 2007-01-09 Impact factor: 22.113

6. AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH.

Authors: Ingrid Liiv; Uku Haljasorg; Kai Kisand; Julia Maslovskaja; Martti Laan; Pärt Peterson
Journal: Biochem Biophys Res Commun Date: 2012-05-18 Impact factor: 3.575

7. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Authors: Yu Hikosaka; Takeshi Nitta; Izumi Ohigashi; Kouta Yano; Naozumi Ishimaru; Yoshio Hayashi; Mitsuru Matsumoto; Koichi Matsuo; Josef M Penninger; Hiroshi Takayanagi; Yoshifumi Yokota; Hisakata Yamada; Yasunobu Yoshikai; Jun-Ichiro Inoue; Taishin Akiyama; Yousuke Takahama
Journal: Immunity Date: 2008-09-19 Impact factor: 31.745

8. Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.

Authors: Zoltan Varecza; Krisztian Kvell; Gergely Talabér; Gyorgy Miskei; Veronika Csongei; Domokos Bartis; Graham Anderson; Eric J Jenkinson; Judit E Pongracz
Journal: Mech Ageing Dev Date: 2011-04-27 Impact factor: 5.432

9. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells.

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10. RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.

Authors: Simona W Rossi; Mi-Yeon Kim; Andreas Leibbrandt; Sonia M Parnell; William E Jenkinson; Stephanie H Glanville; Fiona M McConnell; Hamish S Scott; Josef M Penninger; Eric J Jenkinson; Peter J L Lane; Graham Anderson
Journal: J Exp Med Date: 2007-05-14 Impact factor: 14.307

10 in total

1. Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.

Authors: Ki Yeon Kim; Gwanghee Lee; Minsang Yoon; Eun Hye Cho; Chan-Sik Park; Moon Gyo Kim
Journal: Mol Cells Date: 2015-05-27 Impact factor: 5.034

Review 2. The RANKL-RANK Axis: A Bone to Thymus Round Trip.

Authors: Cristina Sobacchi; Ciro Menale; Anna Villa
Journal: Front Immunol Date: 2019-03-29 Impact factor: 7.561

Review 3. Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.

Authors: Xueyang Bao; Yingyu Qin; Linrong Lu; Mingzhu Zheng
Journal: Front Immunol Date: 2022-03-31 Impact factor: 7.561

Review 4. The Therapeutic Potential of Targeting NIK in B Cell Malignancies.

Authors: Marco V Haselager; Eric Eldering
Journal: Front Immunol Date: 2022-07-12 Impact factor: 8.786

Review 5. Defending and integrating an organism by the immune system.

Authors: Zlatko Dembic
Journal: Scand J Immunol Date: 2022-05 Impact factor: 3.889

6. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells.

Authors: Lina Sun; Chenming Sun; Zhanfeng Liang; Hongran Li; Lin Chen; Haiying Luo; Hongmei Zhang; Pengbo Ding; Xiaoning Sun; Zhihai Qin; Yong Zhao
Journal: Sci Rep Date: 2015-10-08 Impact factor: 4.379

7. Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants.

Authors: Carlos Alberto Moreira-Filho; Silvia Yumi Bando; Fernanda Bernardi Bertonha; Filipi Nascimento Silva; Luciano da Fontoura Costa; Leandro Rodrigues Ferreira; Glaucio Furlanetto; Paulo Chacur; Maria Claudia Nogueira Zerbini; Magda Carneiro-Sampaio
Journal: Oncotarget Date: 2016-02-16