BACKGROUND: Long-term exercise interventions have been shown to improve vital capacity in cystic fibrosis (CF). Yet, no data are available indicating positive effects of long-term exercise training on FEV1. METHODS:39 Swiss patients with CF were randomly divided into strength training (ST, n=12), endurance training (AT, n=17) and controls (CON(CH), n=10), and also compared with age-matched Swiss (n=35) and German (n=701) CF registry data. A partially supervised training of 3×30 min/week for 6 months took place with measurements at baseline and after 3, 6, 12 and 24 months. Primary outcome was FEV1 at 6 months. RESULTS:FEV1 increased significantly in both training groups compared with CON(CH) (AT:+5.8±0.95, ST:+7.4±2.5, CON(CH):-11.5±2.7% predicted, p<0.001) and both registry groups at 6 months. At 24 months, changes in favour of the training groups persisted marginally compared with CONCH, but not compared with registry data. CONCLUSIONS: A partially supervised training over 6 months improved FEV1 but effects were basically gone 18 months off training. Regular long-term training should be promoted as essential part of treatment in CF.
RCT Entities:
BACKGROUND: Long-term exercise interventions have been shown to improve vital capacity in cystic fibrosis (CF). Yet, no data are available indicating positive effects of long-term exercise training on FEV1. METHODS: 39 Swiss patients with CF were randomly divided into strength training (ST, n=12), endurance training (AT, n=17) and controls (CON(CH), n=10), and also compared with age-matched Swiss (n=35) and German (n=701) CF registry data. A partially supervised training of 3×30 min/week for 6 months took place with measurements at baseline and after 3, 6, 12 and 24 months. Primary outcome was FEV1 at 6 months. RESULTS: FEV1 increased significantly in both training groups compared with CON(CH) (AT:+5.8±0.95, ST:+7.4±2.5, CON(CH):-11.5±2.7% predicted, p<0.001) and both registry groups at 6 months. At 24 months, changes in favour of the training groups persisted marginally compared with CONCH, but not compared with registry data. CONCLUSIONS: A partially supervised training over 6 months improved FEV1 but effects were basically gone 18 months off training. Regular long-term training should be promoted as essential part of treatment in CF.
Authors: Helge Hebestreit; Larry C Lands; Nancy Alarie; Jonathan Schaeff; Chantal Karila; David M Orenstein; Don S Urquhart; Erik H J Hulzebos; Lothar Stein; Christian Schindler; Susi Kriemler; Thomas Radtke Journal: BMC Pulm Med Date: 2018-02-08 Impact factor: 3.317
Authors: Ronen Reuveny; Fred J DiMenna; Cedric Gunaratnam; Avigdor D Arad; Gerry N McElvaney; Davide Susta; Michael Peled; Niall M Moyna Journal: BMC Sports Sci Med Rehabil Date: 2020-04-13
Authors: Joseph M Collaco; Scott M Blackman; Karen S Raraigh; Christopher B Morrow; Garry R Cutting; Shruti M Paranjape Journal: BMC Pulm Med Date: 2014-10-06 Impact factor: 3.317
Authors: Mark H Eckman; Elizabeth J Kopras; Karen Montag-Leifling; Lari P Kirby; Lisa Burns; Veronica M Indihar; Patricia M Joseph Journal: MDM Policy Pract Date: 2017-06-23