| Literature DB >> 23587698 |
Chun-Kai Fang1, Hong-Wen Chen, Wei-Hsun Wang, Ren-Shen Liu, Jeng-Jong Hwang.
Abstract
In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [(18)F]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [(18)F]FDOPA injections, rats were then sacrificed at 2 h post [(18)F]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine>methamphetamine>cocaine.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23587698 DOI： 10.1016/j.apradiso.2013.03.091
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513