Literature DB >> 23587482

MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry.

Xiaoqing Cao1, Jue Wang, Zhenhua Wang, Juan Du, Xin Yuan, Weicong Huang, Jian Meng, Haiyong Gu, Yu Nie, Bingyang Ji, Shengshou Hu, Zhe Zheng.   

Abstract

Recent studies demonstrated that the mammalian heart possesses some capacity to proliferate. We observed cardiomyocyte proliferation within 4 weeks of age (P4W) in rats. We found 95 microRNAs that are differentially expressed in P4W cardiomyocytes. MicroRNA-29a was among the most highly up-regulated microRNAs in P4W cardiomyocytes. Overexpression of microRNA-29a suppressed the proliferation of H9c2 cell line. MicroRNA-29a inhibition induced cardiomyocytes to proliferate, accelerated the G1/S and G2/M transition, and up-regulated the cell cycle gene expression. Cyclin D2 (CCND2) was identified as a direct target of microRNA-29a. These findings indicate that microRNA-29a is involved in cardiomyocyte proliferation during postnatal development. Crown
Copyright © 2013. Published by Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23587482     DOI： 10.1016/j.febslet.2013.01.075

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

1.  RNA mimics as therapeutics for cardiac regeneration: a paradigm shift.

Authors:  Mauro Giacca
Journal:  Mol Ther       Date:  2015-06       Impact factor: 11.454

Review 2.  Understanding cardiomyocyte proliferation: an insight into cell cycle activity.

Authors:  Murugavel Ponnusamy; Pei-Feng Li; Kun Wang
Journal:  Cell Mol Life Sci       Date:  2016-09-30       Impact factor: 9.261

3.  Exosomal microRNA-29a mediates cardiac dysfunction and mitochondrial inactivity in obesity-related cardiomyopathy.

Authors:  Fengqin Li; Kuikui Zhang; Ting Xu; Wenjuan Du; Bo Yu; Youbin Liu; Honggang Nie
Journal:  Endocrine       Date:  2018-09-27       Impact factor: 3.633

4.  Evidence That Up-Regulation of MicroRNA-29 Contributes to Postnatal Body Growth Deceleration.

Authors:  Fariha Kamran; Anenisia C Andrade; Aikaterini A Nella; Samuel J Clokie; Geoffrey Rezvani; Ola Nilsson; Jeffrey Baron; Julian C Lui
Journal:  Mol Endocrinol       Date:  2015-04-13

5.  miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival.

Authors:  Yanfei Yang; Dominic P Del Re; Noritsugu Nakano; Sebastiano Sciarretta; Peiyong Zhai; Jiyeon Park; Danish Sayed; Akihiro Shirakabe; Shoji Matsushima; Yongkyu Park; Bin Tian; Maha Abdellatif; Junichi Sadoshima
Journal:  Circ Res       Date:  2015-09-02       Impact factor: 17.367

6.  Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Authors:  Kemal Marc Akat; D'Vesharronne Moore-McGriff; Pavel Morozov; Miguel Brown; Tasos Gogakos; Joel Correa Da Rosa; Aleksandra Mihailovic; Markus Sauer; Ruiping Ji; Aarthi Ramarathnam; Hana Totary-Jain; Zev Williams; Thomas Tuschl; P Christian Schulze
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-10       Impact factor: 11.205

7.  Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields.

Authors:  Yong Liu; Wen-Bin Liu; Kai-Jun Liu; Lin Ao; Jia Cao; Julia Li Zhong; Jin-Yi Liu
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534

Review 8.  Cardiac Regeneration and Stem Cells.

Authors:  Yiqiang Zhang; John Mignone; W Robb MacLellan
Journal:  Physiol Rev       Date:  2015-10       Impact factor: 37.312

9.  Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry.

Authors:  Yiqiang Zhang; Noriko Matsushita; Tamar Eigler; Eduardo Marbán
Journal:  J Regen Med       Date:  2013

Review 10.  The role of microRNAs in cardiac development and regenerative capacity.

Authors:  Michael G Katz; Anthony S Fargnoli; Andrew P Kendle; Roger J Hajjar; Charles R Bridges
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-12-23       Impact factor: 4.733
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