Literature DB >> 2358706

Effect of clofazimine on eye in multibacillary leprosy.

I Kaur1, J Ram, B Kumar, S Kaur, V K Sharma.   

Abstract

Seventy-six patients of multibacillary leprosy received clofazimine as part of multidrug therapy (MDT) for periods ranging between 6 and 24 months. Complete ocular examination including slit lamp microscopy and examination of tears was carried out in all these patients. Reddish brown conjunctival and corneal pigmentation was seen in 46% and 53% of the patients respectively. Clofazimine crystals in tears were found in 32% of the patients. Apart from this no other eye changes or symptoms attributable to clofazimine were observed.

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Year:  1990        PMID: 2358706

Source DB:  PubMed          Journal:  Indian J Lepr        ISSN: 0254-9395


  5 in total

Review 1.  Ocular toxicity from systemically administered xenobiotics.

Authors:  Mitan R Gokulgandhi; Aswani Dutt Vadlapudi; Ashim K Mitra
Journal:  Expert Opin Drug Metab Toxicol       Date:  2012-07-18       Impact factor: 4.481

Review 2.  Adapting Clofazimine for Treatment of Cutaneous Tuberculosis by Using Self-Double-Emulsifying Drug Delivery Systems.

Authors:  Daniélle van Staden; Richard K Haynes; Joe M Viljoen
Journal:  Antibiotics (Basel)       Date:  2022-06-15

Review 3.  The Mycobacterium avium complex.

Authors:  C B Inderlied; C A Kemper; L E Bermudez
Journal:  Clin Microbiol Rev       Date:  1993-07       Impact factor: 26.132

4.  Crystalline deposition in the cornea and conjunctiva secondary to long-term clofazimine therapy in a leprosy patient.

Authors:  Rakesh K Barot; Vishalakshi Viswanath; Madhuri S Pattiwar; Raghunandan G Torsekar
Journal:  Indian J Ophthalmol       Date:  2011 Jul-Aug       Impact factor: 1.848

Review 5.  Drug-induced corneal deposits: an up-to-date review.

Authors:  Jean-Yves Sahyoun; Saama Sabeti; Marie-Claude Robert
Journal:  BMJ Open Ophthalmol       Date:  2022-03-25
  5 in total

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