Literature DB >> 23585962

Complete response of 7 years' duration after chemoradiotherapy followed by gefitinib in a patient with intramedullary spinal cord metastasis from lung adenocarcinoma.

Yoshinobu Hata1, Yujiro Takai, Hiroshi Takahashi, Keigo Takagi, Kazutoshi Isobe, Chikako Hasegawa, Kazutoshi Shibuya, Hidenori Goto, Kazuyoshi Tamaki, Fumitomo Sato, Hajime Otsuka.   

Abstract

Intramedullary spinal cord metastasis is a rare but serious complication which causes rapid progression of neurological deficits. Here we report a 35-year-old man presenting with increasing leg pain and gait disturbance, 8 months after surgery for lung adenocarcinoma. Spinal magnetic resonance imaging revealed an intramedullary tumor at the Th7/8 level. Radiotherapy at 35 Gy resulted in transient symptomatic improvement, but during chemotherapy with vinorelbine and cisplatin, symptoms worsened again. Gefitinib was then administered; the patient improved after 2 weeks and has now maintained a complete response for 7 years.

Entities:  

Keywords:  EGFR; Intramedullary spinal cord metastasis; gefitinib; lung cancer; magnetic resonance imaging; positron-emission tomography

Year:  2013        PMID： 23585962      PMCID： PMC3621920          DOI： 10.3978/j.issn.2072-1439.2012.12.09

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN： 2072-1439            Impact factor:   2.895


  15 in total

1.  Treatment options and time course for intramedullary spinal cord metastasis. Report of three cases and review of the literature.

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Journal:  Neurosurg Focus       Date:  1998-05-15       Impact factor: 4.047

2.  Intramedullary spinal cord metastasis: report of three cases and review of the literature.

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Journal:  Surg Neurol       Date:  1996-10

Review 3.  Metastasis to nervous system: spinal epidural and intramedullary metastases.

Authors:  Melike Mut; David Schiff; Mark E Shaffrey
Journal:  J Neurooncol       Date:  2005-10       Impact factor: 4.130

Review 4.  Intramedullary spinal cord metastases: diagnosis and treatment - an illustrated review.

Authors:  M Kalayci; F Cağavi; S Gül; S Yenidünya; B Açikgöz
Journal:  Acta Neurochir (Wien)       Date:  2004-11-08       Impact factor: 2.216

5.  Clinical features and natural history of intramedullary spinal cord metastasis.

Authors:  J L Grem; J Burgess; D L Trump
Journal:  Cancer       Date:  1985-11-01       Impact factor: 6.860

6.  Intramedullary spinal cord metastases: clinical features and treatment outcome.

Authors:  D Schiff; B P O'Neill
Journal:  Neurology       Date:  1996-10       Impact factor: 9.910

7.  Intramedullary spinal cord metastasis: a clinical and imaging study of seven patients.

Authors:  Masahiko Watanabe; Takeshi Nomura; Eiren Toh; Masato Sato; Joji Mochida
Journal:  J Spinal Disord Tech       Date:  2006-02

Review 8.  The new lung cancer staging system.

Authors:  Frank C Detterbeck; Daniel J Boffa; Lynn T Tanoue
Journal:  Chest       Date:  2009-07       Impact factor: 9.410

9.  Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature.

Authors:  G Grasso; F Meli; R Patti; F Giambartino; A M Florena; D G Iacopino
Journal:  Spinal Cord       Date:  2007-07-17       Impact factor: 2.772

10.  Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.

Authors:  A Kalikaki; A Koutsopoulos; M Trypaki; J Souglakos; E Stathopoulos; V Georgoulias; D Mavroudis; A Voutsina
Journal:  Br J Cancer       Date:  2008-09-16       Impact factor: 7.640
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  5 in total

1.  A case of long-term survival after multimodal local treatments of intramedullary spinal cord metastasis of squamous cell lung cancer.

Authors:  Shojiro Minomo; Akihiro Tokoro; Tomoki Utsumi; Masahiro Ishihara; Masanori Akira; Shinji Atagi
Journal:  J Thorac Dis       Date:  2016-08       Impact factor: 2.895

Review 2.  Review of the current targeted therapies for non-small-cell lung cancer.

Authors:  Kim-Son H Nguyen; Joel W Neal; Heather Wakelee
Journal:  World J Clin Oncol       Date:  2014-10-10

3.  Successful osimertinib treatment in a patient who exhibited intramedullary spinal cord metastases of lung adenocarcinoma with an acquired EGFR T790M mutation.

Authors:  Kohei Horiuchi; Takanori Asakura; Shinji Sakaguchi; Fumitake Saito
Journal:  BMJ Case Rep       Date:  2019-06-21

4.  Clinical Features, Treatments, and Prognosis of Intramedullary Spinal Cord Metastases From Lung Cancer: A Case Series and Systematic Review.

Authors:  Liang Wu; Li'ao Wang; Jun Yang; Wenqing Jia; Yulun Xu
Journal:  Neurospine       Date:  2022-02-03

5.  Advanced lung adenocarcinoma with spinal cord metastasis successfully treated with second EGFR-TKI treatment: a case report and literature review.

Authors:  Xiaoyan Li; Hui Yang; Jing Zhao; Hongjun Gao
Journal:  Onco Targets Ther       Date:  2015-09-29       Impact factor: 4.147
  5 in total

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