OBJECTIVE: Overtime, malignant pleural effusion (MPE) arises in advanced-stages of malignancies and frequently heralds a poor prognosis. If the underlying malignancy is chemo sensitive, systemic chemotherapy may control pleural effusion. A common method for the management of the patients with refractory MPE is pleurodesis through the introduction of sclerosing agents such as talc, bleomycin administered/instilled into the pleural cavity. However, the present prospective study aimed to investigate the efficacy and safety of pleurodesis with povidone-iodine (Betadine) in patients with MPE admitted in Sari General Hospital during 2008-2011. METHODS: Thirty-six patients who underwent pleurodesis by instilling povidone-iodine through a thoracostomy tube, as a bedside procedure were enrolled in the study. For evaluating the effect of povidone-iodine on thyroid gland, the authors measured the thyroid function tests before and after the pleurodesis at 1 week. RESULTS: The response to this procedure was complete in 26 patients (72.2%) and partial in 7 patients (19.4%). Treatment failure was displayed in 3 patients (8.3%). The overall success rate was 91.6%. In post-procedure, the most common complaints of the patients were pain (35.9%) followed by dyspnea, burning and fever. Povidone-iodine does not affect on thyroid function tests. CONCLUSIONS: Povidone-iodine is an effective, inexpensive, safe and feasible agent for chemical pleurodesis in management of MPE.
OBJECTIVE: Overtime, malignant pleural effusion (MPE) arises in advanced-stages of malignancies and frequently heralds a poor prognosis. If the underlying malignancy is chemo sensitive, systemic chemotherapy may control pleural effusion. A common method for the management of the patients with refractory MPE is pleurodesis through the introduction of sclerosing agents such as talc, bleomycin administered/instilled into the pleural cavity. However, the present prospective study aimed to investigate the efficacy and safety of pleurodesis with povidone-iodine (Betadine) in patients with MPE admitted in Sari General Hospital during 2008-2011. METHODS: Thirty-six patients who underwent pleurodesis by instilling povidone-iodine through a thoracostomy tube, as a bedside procedure were enrolled in the study. For evaluating the effect of povidone-iodine on thyroid gland, the authors measured the thyroid function tests before and after the pleurodesis at 1 week. RESULTS: The response to this procedure was complete in 26 patients (72.2%) and partial in 7 patients (19.4%). Treatment failure was displayed in 3 patients (8.3%). The overall success rate was 91.6%. In post-procedure, the most common complaints of the patients were pain (35.9%) followed by dyspnea, burning and fever. Povidone-iodine does not affect on thyroid function tests. CONCLUSIONS:Povidone-iodine is an effective, inexpensive, safe and feasible agent for chemical pleurodesis in management of MPE.
Authors: Carlos A Olivares-Torres; Rafael Laniado-Laborín; Cesáreo Chávez-García; César León-Gastelum; Alberto Reyes-Escamilla; Richard W Light Journal: Chest Date: 2002-08 Impact factor: 9.410
Authors: Alfonso Fiorelli; Francesca Pentimalli; Vittorio D'Urso; Domenico Di Marzo; Iris Maria Forte; Antonio Giordano; Marina Di Domenico; Marina Accardo; Umberto Di Serio; Mario Santini Journal: Eur J Cardiothorac Surg Date: 2014-01-06 Impact factor: 4.191