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Literature DB >> 23585768

An in vitro-in vivo model of epithelial mesenchymal transition in triple negative breast cancer.

Yubo Zhai¹, Julia Santucci-Pereira, Ricardo Lopez de Cicco, Irma H Russo, Jose Russo.

Abstract

The loss of epithelial expression markers by neoplastic breast cancer cells in the primary tumor is believed to play a pivotal role during breast cancer metastasis. This phenomenon is the hallmark of the epithelial mesenchymal transition (EMT) process. Gene expression microarrays were performed to investigate key functional elements on an in vitro metastasis model derived from human breast epithelial cells (MCF10F) treated with 17 beta estradiol. We identified groups of SLUG associated genes modulated during EMT.

Entities: CellLine Chemical Disease Gene Species

Year: 2012 PMID： 23585768 PMCID： PMC3622948 DOI： 10.1016/j.ddmec.2012.11.002

Source DB: PubMed Journal: Drug Discov Today Dis Mech ISSN： 1740-6765

45 in total

1. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.

Authors: Carl R Schmidt; Y J Gi; Trusharth A Patel; Robert J Coffey; R Daniel Beauchamp; A Scott Pearson
Journal: Surgery Date: 2005-08 Impact factor: 3.982

2. Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.

Authors: Manale Karam; Christine Legay; Christian Auclair; Jean-Marc Ricort
Journal: Exp Cell Res Date: 2012-01-08 Impact factor: 3.905

3. A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.

Authors: W P Bocchinfuso; W P Hively; J F Couse; H E Varmus; K S Korach
Journal: Cancer Res Date: 1999-04-15 Impact factor: 12.701

An in vitro-in vivo model of epithelial mesenchymal transition in triple negative breast cancer.

1. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.

2. Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.

3. A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.

Review 4. The EMT regulator slug and lung carcinogenesis.

5. Slug regulates proliferation and invasiveness of esophageal adenocarcinoma cells in vitro and in vivo.

6. Ultrastructural and immunocytochemical characterization of an immortalized human breast epithelial cell line, MCF-10.

7. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.

8. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.

Review 9. Basal breast cancer: a complex and deadly molecular subtype.

Review 10. The extracellular matrix: a dynamic niche in cancer progression.

1. Preface.

2. The etiology and prevention of breast cancer.

3. Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells.