Literature DB >> 23585600

Is caffeine consumption safe during pregnancy?

Sara Morgan1, Gideon Koren, Pina Bozzo.   

Abstract

QUESTION: I have a pregnant patient who experienced a miscarriage in the past and who has asked me whether her consumption of 2 cups of coffee per day could have caused it. What should I tell her? ANSWER: There are conflicting data on the fetal safety of dietary caffeine consumption during pregnancy, particularly at levels of 300 mg/d or greater. Although it is difficult to assess the risk of spontaneous abortion with caffeine consumption, most of the data do not suggest an increased risk of adverse pregnancy, fertility, or neurodevelopmental outcomes with caffeine consumption of 300 mg/d or less from all sources. Therefore, consumption of 1 to 2 cups of coffee a day is not expected to be a concern.

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Year:  2013        PMID: 23585600      PMCID: PMC3625078     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN: 0008-350X            Impact factor:   3.275


  13 in total

1.  Passage of caffeine into human gonadal and fetal tissue.

Authors:  A GOLDSTEIN; R WARREN
Journal:  Biochem Pharmacol       Date:  1962-02       Impact factor: 5.858

Review 2.  Maternal caffeine consumption and spontaneous abortion: a review of the epidemiologic evidence.

Authors:  Lisa B Signorello; Joseph K McLaughlin
Journal:  Epidemiology       Date:  2004-03       Impact factor: 4.822

Review 3.  Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

Authors:  B B Fredholm; K Bättig; J Holmén; A Nehlig; E E Zvartau
Journal:  Pharmacol Rev       Date:  1999-03       Impact factor: 25.468

4.  A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update.

Authors:  Jennifer David Peck; Alan Leviton; Linda D Cowan
Journal:  Food Chem Toxicol       Date:  2010-06-15       Impact factor: 6.023

5.  Caffeine intake during pregnancy and risk of problem behavior in 5- to 6-year-old children.

Authors:  Eva M Loomans; Laura Hofland; Odin van der Stelt; Marcel F van der Wal; Hans M Koot; Bea R H Van den Bergh; Tanja G M Vrijkotte
Journal:  Pediatrics       Date:  2012-07-09       Impact factor: 7.124

6.  Intrauterine exposure to caffeine and inattention/overactivity in children.

Authors:  M Bekkhus; T Skjøthaug; R Nordhagen; A I H Borge
Journal:  Acta Paediatr       Date:  2010-03-05       Impact factor: 2.299

7.  The disposition of caffeine during and after pregnancy.

Authors:  A Aldridge; J Bailey; A H Neims
Journal:  Semin Perinatol       Date:  1981-10       Impact factor: 3.300

8.  Caffeine intake and delayed conception: a European multicenter study on infertility and subfecundity. European Study Group on Infertility Subfecundity.

Authors:  F Bolúmar; J Olsen; M Rebagliato; L Bisanti
Journal:  Am J Epidemiol       Date:  1997-02-15       Impact factor: 4.897

9.  The effect of caffeine consumption on the success rate of pregnancy as well various performance parameters of in-vitro fertilization treatment.

Authors:  Iman Al-Saleh; Inaam El-Doush; Bellido Grisellhi; Serdar Coskun
Journal:  Med Sci Monit       Date:  2010-12

Review 10.  Effects of caffeine on development and behavior in infancy and childhood: a review of the published literature.

Authors:  F X Castellanos; J L Rapoport
Journal:  Food Chem Toxicol       Date:  2002-09       Impact factor: 6.023

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  3 in total

1.  Placenta-on-a-Chip: In Vitro Study of Caffeine Transport across Placental Barrier Using Liquid Chromatography Mass Spectrometry.

Authors:  Rajeendra L Pemathilaka; Jeremy D Caplin; Saurabh S Aykar; Reza Montazami; Nicole N Hashemi
Journal:  Glob Chall       Date:  2019-02-18

2.  In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study.

Authors:  Hannah E Laue; Yike Shen; Tessa R Bloomquist; Haotian Wu; Kasey J M Brennan; Raphael Cassoulet; Erin Wilkie; Virginie Gillet; Anne-Sandrine Desautels; Nadia Abdelouahab; Jean Philippe Bellenger; Heather H Burris; Brent A Coull; Marc G Weisskopf; Wei Zhang; Larissa Takser; Andrea A Baccarelli
Journal:  Int J Environ Res Public Health       Date:  2022-07-30       Impact factor: 4.614

Review 3.  Environmental & occupational exposure & female reproductive dysfunction.

Authors:  Sunil Kumar; Anupama Sharma; Chaoba Kshetrimayum
Journal:  Indian J Med Res       Date:  2019-12       Impact factor: 2.375

  3 in total

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