Literature DB >> 2358424

Determination of the disulfide array in sapecin, an antibacterial peptide of Sarcophaga peregrina (flesh fly).

T Kuzuhara1, Y Nakajima, K Matsuyama, S Natori.   

Abstract

Sapecin is a 40-residue peptide containing 6 half-cystine residues. The disulfide structure of sapecin was determined by sequencing cystine-containing peptides obtained by digesting sapecin with thermolysin. Results showed that sapecin has a vortical structure fixed by 3 disulfide bonds between cysteine residues 3 and 30, 16 and 36, and 20 and 38, respectively, and that these disulfide bonds are essential for its antibacterial activity.

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Year:  1990        PMID： 2358424     DOI： 10.1093/oxfordjournals.jbchem.a123077

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  10 in total

1.  Two-dimensional 1H NMR study of recombinant insect defensin A in water: resonance assignments, secondary structure and global folding.

Authors:  J M Bonmatin; J L Bonnat; X Gallet; F Vovelle; M Ptak; J M Reichhart; J A Hoffmann; E Keppi; M Legrain; T Achstetter
Journal:  J Biomol NMR       Date:  1992-05       Impact factor: 2.835

2.  Antimicrobial actions of human and macaque sperm associated antigen (SPAG) 11 isoforms: influence of the N-terminal peptide.

Authors:  Suresh Yenugu; Katherine G Hamil; Frank S French; Susan H Hall
Journal:  Mol Cell Biochem       Date:  2006-01-13       Impact factor: 3.396

3.  Identification and characterization of the antimicrobial peptide corresponding to C-terminal beta-sheet domain of tenecin 1, an antibacterial protein of larvae of Tenebrio molitor.

Authors:  K H Lee; S Y Hong; J E Oh; M Kwon; J H Yoon; J Lee; B L Lee; H M Moon
Journal:  Biochem J       Date:  1998-08-15       Impact factor: 3.857

4.  Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli.

Authors:  Suresh Yenugu; Katherine G Hamil; Charles E Birse; Steven M Ruben; Frank S French; Susan H Hall
Journal:  Biochem J       Date:  2003-06-01       Impact factor: 3.857

5.  Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.

Authors:  S Cociancich; A Dupont; G Hegy; R Lanot; F Holder; C Hetru; J A Hoffmann; P Bulet
Journal:  Biochem J       Date:  1994-06-01       Impact factor: 3.857

6.  Probing protein folding and stability using disulfide bonds.

Authors:  N Darby; T E Creighton
Journal:  Mol Biotechnol       Date:  1997-02       Impact factor: 2.695

7.  Purification, sequence and antibacterial activity of two novel sapecin homologues from Sarcophaga embryonic cells: similarity of sapecin B to charybdotoxin.

Authors:  K Yamada; S Natori
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

8.  Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: possible new targets of pharmacologic agents.

Authors:  Lajos Nagy; Miki Nagata; Sandor Szabo
Journal:  World J Gastroenterol       Date:  2007-04-14       Impact factor: 5.742

9.  The fate of the prosegment in the acute-phase and programmed synthesis of sapecin, an antibacterial peptide of the flesh fly (Sarcophaga peregrina).

Authors:  K Homma; K Matsuyama; H Komano; S Natori
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

Review 10.  Molecules participating in insect immunity of Sarcophaga peregrina.

Authors:  Shunji Natori
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493
  10 in total

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