| Literature DB >> 2358406 |
S Morimoto1, T Adachi, Y Misawa, T Nagate, Y Watanabe, S Omura.
Abstract
6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.Entities:
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Year: 1990 PMID： 2358406 DOI： 10.7164/antibiotics.43.544
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649