Literature DB >> 23584015

Gold amides as anticancer drugs: synthesis and activity studies.

Sonya Newcombe1, Mariusz Bobin, Amruta Shrikhande, Chris Gallop, Yannick Pace, Helen Yong, Rebecca Gates, Shuvashri Chaudhuri, Mark Roe, Eva Hoffmann, Eddy M E Viseux.   

Abstract

Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

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Year:  2013        PMID: 23584015     DOI: 10.1039/c3ob27460h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

1.  Synthesis, characterization and luminescence studies of gold(I)-NHC amide complexes.

Authors:  Adrián Gómez-Suárez; David J Nelson; David G Thompson; David B Cordes; Duncan Graham; Alexandra M Z Slawin; Steven P Nolan
Journal:  Beilstein J Org Chem       Date:  2013-10-28       Impact factor: 2.883

Review 2.  Triflamides and Triflimides: Synthesis and Applications.

Authors:  Mikhail Y Moskalik; Vera V Astakhova
Journal:  Molecules       Date:  2022-08-15       Impact factor: 4.927

  2 in total

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