| Literature DB >> 23584015 |
Sonya Newcombe1, Mariusz Bobin, Amruta Shrikhande, Chris Gallop, Yannick Pace, Helen Yong, Rebecca Gates, Shuvashri Chaudhuri, Mark Roe, Eva Hoffmann, Eddy M E Viseux.
Abstract
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.Entities:
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Year: 2013 PMID: 23584015 DOI: 10.1039/c3ob27460h
Source DB: PubMed Journal: Org Biomol Chem ISSN: 1477-0520 Impact factor: 3.876