| Literature DB >> 23583447 |
Rio Nishibe1, Wataru Watanabe, Takeshi Ueda, Norimasa Yamasaki, Richard Koller, Linda Wolff, Zen-ichiro Honda, Motoaki Ohtsubo, Hiroaki Honda.
Abstract
CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-deficient (Ciz1(-/-)) mice grew without any obvious abnormalities, and Ciz1(-/-) mouse embryonic fibroblasts (MEFs) did not show any defects in cell cycle status, cell growth, and DNA damage response. However, Ciz1(-/-) MEFs were sensitive to hydroxyurea-mediated replication stress and susceptible to oncogene-induced cellular transformation. In addition, Ciz1(-/-) mice developed various types of leukemias by retroviral insertional mutagenesis. These results indicate that CIZ1 functions as a tumor suppressor in vivo.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23583447 DOI： 10.1016/j.febslet.2013.03.034
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124