Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Immunoglobulin genes and the acquisition of HIV infection in a randomized trial of recombinant adenovirus HIV vaccine.

Literature DB >> 23582638

Immunoglobulin genes and the acquisition of HIV infection in a randomized trial of recombinant adenovirus HIV vaccine.

Janardan P Pandey¹, Aryan M Namboodiri, Shizhong Bu, Jean De Dieu Tapsoba, Alicia Sato, James Y Dai.

Abstract

Our knowledge of the host genetic factors that contribute to the acquisition of HIV infection is limited. To identify the host genetic correlates of HIV1 acquisition, we genotyped 777 participants of a randomized trial of recombinant adenovirus HIV1 vaccine for Fcγ receptor IIa (FcγRIIa), FcγRIIIa, and several GM and KM alleles-genetic markers of immunoglobulin γ and κ chains, respectively. None of the genotypes by itself was significantly associated with the acquisition of HIV1 infection. However, particular combinations of GM and KM as well as those of GM and FcγRIIIa loci were significantly associated with the acquisition of HIV1 infection epistatically: KM1/3-GM3/17 (interaction p=0.0246; FDR=0.2952), KM1/3-GM5/21 (interaction p=0.0016; FDR=0.0960), and GM23+/-FcγRIIIa (interaction p=0.0060; FDR=0.1200). These results suggest the involvement of GM, KM, and FcγRIIIa loci in the acquisition of HIV infection. Additional studies are warranted.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2013 PMID： 23582638 PMCID： PMC3750738 DOI： 10.1016/j.virol.2013.03.007

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

22 in total

1. Determination of allotypes G1m(f) and G1m(z) at the genomic level by subclass-specific amplification of DNA and use of allele-specific probes.

Authors: M Balbín; A Grubb; M Abrahamson; R Grubb
Journal: Exp Clin Immunogenet Date: 1991

2. Molecular characterization of Gm(n+) and G2m(n-) allotypes.

Authors: A Brusco; G G de Lange; C Boccazzi; A O Carbonara
Journal: Immunogenetics Date: 1995 Impact factor: 2.846

3. Highly preferential VH-VL pairing in normal B cells results in antigen-independent selection of the available repertoire.

Authors: D Primi; A M Drapier; P A Cazenave
Journal: J Immunol Date: 1987-03-01 Impact factor: 5.422

4. Interactive effect of Gm and Km allotypes on cellular immune responses to streptococcal cell wall antigen.

Authors: R R Wachsmuth; J P Pandey; J A Fedrick; Y Nishimura; T Sasazuki
Journal: Exp Clin Immunogenet Date: 1987

5. DNA sequences specific for Caucasian G3m(b) and (g) allotypes: allotyping at the genomic level.

Authors: M Balbín; A Grubb; G G de Lange; R Grubb
Journal: Immunogenetics Date: 1994 Impact factor: 2.846

6. HLA-and Gm-linked genes affecting the degradation rate of antigens (sheep red blood cells) endocytized by macrophages.

Authors: L Legrand; L Rivat-Perran; C Huttin; J Dausset
Journal: Hum Immunol Date: 1982-02 Impact factor: 2.850

7. Immunoglobulin allotypes and immunoreactivity in chronic liver disease.

Authors: W Schmidt; B Königstedt; B Zipprich; E Scheibe; R Nilius
Journal: Hepatogastroenterology Date: 1987-10

8. The herpes simplex virus type 1 Fc receptor discriminates between IgG1 allotypes.

Authors: A Atherton; K L Armour; S Bell; A C Minson; M R Clark
Journal: Eur J Immunol Date: 2000-09 Impact factor: 5.532

9. Polymerase chain reaction-based genotyping for allotypic markers of immunoglobulin kappa shows allelic association of Km with kappa variable segment.

Authors: G Moxley; R S Gibbs
Journal: Genomics Date: 1992-05 Impact factor: 5.736

10. Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study).

Authors: Ann Duerr; Yunda Huang; Susan Buchbinder; Robert W Coombs; Jorge Sanchez; Carlos del Rio; Martin Casapia; Steven Santiago; Peter Gilbert; Lawrence Corey; Michael N Robertson
Journal: J Infect Dis Date: 2012-05-04 Impact factor: 5.226

12 in total

Review 1. The role of Fc receptors in HIV infection and vaccine efficacy.

Authors: Sarah L Cocklin; Joern E Schmitz
Journal: Curr Opin HIV AIDS Date: 2014-05 Impact factor: 4.283

2. Genetic variants of Fcγ (GM allotypes) and the Fc-mediated effector functions in HIV-1 controllers.

Authors: Janardan P Pandey
Journal: J Virol Date: 2014-06 Impact factor: 5.103

3. FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial.

Authors: Shuying S Li; Peter B Gilbert; Georgia D Tomaras; Gustavo Kijak; Guido Ferrari; Rasmi Thomas; Chul-Woo Pyo; Susan Zolla-Pazner; David Montefiori; Hua-Xin Liao; Gary Nabel; Abraham Pinter; David T Evans; Raphael Gottardo; James Y Dai; Holly Janes; Daryl Morris; Youyi Fong; Paul T Edlefsen; Fusheng Li; Nicole Frahm; Michael D Alpert; Heather Prentice; Supachai Rerks-Ngarm; Punnee Pitisuttithum; Jaranit Kaewkungwal; Sorachai Nitayaphan; Merlin L Robb; Robert J O'Connell; Barton F Haynes; Nelson L Michael; Jerome H Kim; M Juliana McElrath; Daniel E Geraghty
Journal: J Clin Invest Date: 2014-08-08 Impact factor: 14.808

Review 9. Immunoglobulin GM Genes, Cytomegalovirus Immunoevasion, and the Risk of Glioma, Neuroblastoma, and Breast Cancer.

Authors: Janardan P Pandey
Journal: Front Oncol Date: 2014-08-29 Impact factor: 6.244

10. FCGR2A and FCGR3A Genotypes in Human Immunodeficiency Virus Mother-to-Child Transmission.

Authors: Caitlin Milligan; Barbra A Richardson; Grace John-Stewart; Ruth Nduati; Julie Overbaugh
Journal: Open Forum Infect Dis Date: 2015-10-14 Impact factor: 3.835