| Literature DB >> 23582084 |
Cong-Dat Pham1, Horst Weber, Rudolf Hartmann, Victor Wray, Wenhan Lin, Daowan Lai, Peter Proksch.
Abstract
Two new alkaloids, polycarpathiamines A and B (1 and 2), were isolated from the ascidian Polycarpa aurata. Their structures were unambiguously determined by 1D, 2D NMR, and HRESIMS measurements and further confirmed by comparison with a closely related analogue, 3-dimethylamino-5-benzoyl-1,2,4-thiadiazole (4), that was prepared by chemical synthesis. Compounds 1 and 2 both feature an uncommon 1,2,4-thiadiazole ring whose biosynthetic origin is proposed. Compound 1 showed significant cytotoxic activity against L5178Y murine lymphoma cells (IC50 0.41 μM).Entities:
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Year: 2013 PMID： 23582084 DOI： 10.1021/ol400791n
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005