Literature DB >> 23581530

5-Oxo-ETE receptor antagonists.

Vivek Gore1, Pranav Patel, Chih-Tsung Chang, Sashikala Sivendran, Namin Kang, Yannick P Ouedraogo, Sylvie Gravel, William S Powell, Joshua Rokach.   

Abstract

5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23581530      PMCID： PMC3800034          DOI： 10.1021/jm400480j

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  21 in total

1.  Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3.

Authors:  S Sozzani; D Zhou; M Locati; S Bernasconi; W Luini; A Mantovani; J T O'Flaherty
Journal:  J Immunol       Date:  1996-11-15       Impact factor: 5.422

2.  5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils.

Authors:  M Guilbert; C Ferland; M Bossé; N Flamand; S Lavigne; M Laviolette
Journal:  Am J Respir Cell Mol Biol       Date:  1999-07       Impact factor: 6.914

3.  Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.

Authors:  Sathish Sundaram; Jagadananda Ghosh
Journal:  Biochem Biophys Res Commun       Date:  2005-11-08       Impact factor: 3.575

Review 4.  Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE.

Authors:  William S Powell; Joshua Rokach
Journal:  Prog Lipid Res       Date:  2005-04-20       Impact factor: 16.195

5.  5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.

Authors:  W S Powell; D Chung; S Gravel
Journal:  J Immunol       Date:  1995-04-15       Impact factor: 5.422

6.  Receptors for the 5-oxo class of eicosanoids in neutrophils.

Authors:  J T O'Flaherty; J S Taylor; M J Thomas
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

7.  5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils.

Authors:  W S Powell; S Gravel; F Halwani
Journal:  Am J Respir Cell Mol Biol       Date:  1999-01       Impact factor: 6.914

8.  5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes.

Authors:  J T O'Flaherty; M Kuroki; A B Nixon; J Wijkander; E Yee; S L Lee; P K Smitherman; R L Wykle; L W Daniel
Journal:  J Immunol       Date:  1996-07-01       Impact factor: 5.422

9.  Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets.

Authors:  W S Powell; S Gravel; S P Khanapure; J Rokach
Journal:  Blood       Date:  1999-02-01       Impact factor: 22.113

10.  5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements.

Authors:  U Schwenk; J M Schröder
Journal:  J Biol Chem       Date:  1995-06-23       Impact factor: 5.157
View more
  8 in total

1.  Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists.

Authors:  Vivek Gore; Sylvie Gravel; Chantal Cossette; Pranav Patel; Shishir Chourey; Qiuji Ye; Joshua Rokach; William S Powell
Journal:  J Med Chem       Date:  2014-01-06       Impact factor: 7.446

Review 2.  The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor.

Authors:  William S Powell; Joshua Rokach
Journal:  Prog Lipid Res       Date:  2013-09-19       Impact factor: 16.195

Review 3.  Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.

Authors:  William S Powell; Joshua Rokach
Journal:  Biochim Biophys Acta       Date:  2014-10-29

Review 4.  Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.

Authors:  Magnus Bäck; William S Powell; Sven-Erik Dahlén; Jeffrey M Drazen; Jilly F Evans; Charles N Serhan; Takao Shimizu; Takehiko Yokomizo; G Enrico Rovati
Journal:  Br J Pharmacol       Date:  2014-07-12       Impact factor: 8.739

5.  Two Potent OXE-R Antagonists: Assignment of Stereochemistry.

Authors:  Pranav Patel; Chintam Nagendra Reddy; Vivek Gore; Shishir Chourey; Qiuji Ye; Yannick P Ouedraogo; Sylvie Gravel; William S Powell; Joshua Rokach
Journal:  ACS Med Chem Lett       Date:  2014-05-29       Impact factor: 4.345

Review 6.  Intercellular Lipid Mediators and GPCR Drug Discovery.

Authors:  Dong-Soon Im
Journal:  Biomol Ther (Seoul)       Date:  2013-11       Impact factor: 4.634

Review 7.  Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs.

Authors:  Anthony M Kyriakopoulos; Markus Nagl; Stella Baliou; Vasilleios Zoumpourlis
Journal:  Int J Inflam       Date:  2017-05-10

8.  Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity.

Authors:  Hao Guo; Iris C Verhoek; Gerian G H Prins; Ramon van der Vlag; Petra E van der Wouden; Ronald van Merkerk; Wim J Quax; Peter Olinga; Anna K H Hirsch; Frank J Dekker
Journal:  J Med Chem       Date:  2019-04-19       Impact factor: 7.446
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.