| Literature DB >> 23578918 |
Abstract
This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.Entities:
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Year: 2011 PMID： 23578918 DOI： 10.1016/j.ctim.2011.08.002
Source DB: PubMed Journal: Complement Ther Med ISSN： 0965-2299 Impact factor: 2.446