OBJECTIVE: This study was undertaken to assess the potential influence of total parenteral nutrition (TPN) on body composition (BC) in preterm infants. STUDY DESIGN: This prospective, observational study of infants born <35 weeks measured BC at discharge using air displacement plethysmography. The % body fat (BF) at discharge was correlated with variables gestational age (GA), severity of illness, days on oxygen, time to regain birth weight and duration of TPN. RESULT: The 61 patients enrolled had a %BF at discharge of 13.9%. GA and TPN days correlated with %BF for the entire group. Multiple regression analysis identified that the time to regain birth weight added to the effect of GA, but not TPN. Isolating the influence of TPN in a subgroup of similarly aged infants (30-35 weeks) did not reveal a difference in body composition at the time of discharge between infants who did or did not receive TPN. CONCLUSION: These findings fail to demonstrate a clear influence of TPN on the increased accrual of BF in premature infants and implicate gestational modification in nutrient/caloric utilization as a principle regulator of body composition in premature newborns.
OBJECTIVE: This study was undertaken to assess the potential influence of total parenteral nutrition (TPN) on body composition (BC) in preterm infants. STUDY DESIGN: This prospective, observational study of infants born <35 weeks measured BC at discharge using air displacement plethysmography. The % body fat (BF) at discharge was correlated with variables gestational age (GA), severity of illness, days on oxygen, time to regain birth weight and duration of TPN. RESULT: The 61 patients enrolled had a %BF at discharge of 13.9%. GA and TPN days correlated with %BF for the entire group. Multiple regression analysis identified that the time to regain birth weight added to the effect of GA, but not TPN. Isolating the influence of TPN in a subgroup of similarly aged infants (30-35 weeks) did not reveal a difference in body composition at the time of discharge between infants who did or did not receive TPN. CONCLUSION: These findings fail to demonstrate a clear influence of TPN on the increased accrual of BF in premature infants and implicate gestational modification in nutrient/caloric utilization as a principle regulator of body composition in premature newborns.
Authors: Lotte E Vlug; Esther G Neelis; Jonathan C K Wells; Mary S Fewtrell; Wendy L M Kastelijn; Joanne F Olieman; Marijn J Vermeulen; Jorine A Roelants; Dimitris Rizopoulos; René M H Wijnen; Edmond H H M Rings; Barbara A E de Koning; Jessie M Hulst Journal: Am J Clin Nutr Date: 2022-02-09 Impact factor: 7.045
Authors: Lea Sophie Möllers; Efrah I Yousuf; Constanze Hamatschek; Katherine M Morrison; Michael Hermanussen; Christoph Fusch; Niels Rochow Journal: Pediatr Res Date: 2021-05-26 Impact factor: 3.953
Authors: Hajar Mazahery; Pamela R von Hurst; Christopher J D McKinlay; Barbara E Cormack; Cathryn A Conlon Journal: Matern Health Neonatol Perinatol Date: 2018-06-20