Literature DB >> 23577982

No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment.

Anne E Bras1, Marry M van den Heuvel-Eibrink, Alita J van der Sluijs-Gelling, Eva A Coenen, Henk Wind, C Michel Zwaan, Jeroen G te Marvelde, Mirjam van der Burg, Brenda Gibson, Anita W Rijneveld, Valérie de Haas, Jacques J M van Dongen, Vincent H J van der Velden.   

Abstract

B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.
© 2013 John Wiley & Sons Ltd.

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Year:  2013        PMID： 23577982     DOI： 10.1111/bjh.12329

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  4 in total

1.  Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome.

Authors:  Michaela Nováková; Markéta Žaliová; Martina Suková; Marcin Wlodarski; Aleš Janda; Eva Froňková; Vít Campr; Kateřina Lejhancová; Ondřej Zapletal; Dagmar Pospíšilová; Zdeňka Černá; Tomáš Kuhn; Peter Švec; Vendula Pelková; Zuzana Zemanová; Gitte Kerndrup; Marry van den Heuvel-Eibrink; Vincent van der Velden; Charlotte Niemeyer; Tomáš Kalina; Jan Trka; Jan Starý; Ondřej Hrušák; Ester Mejstříková
Journal:  Haematologica       Date:  2016-03-24       Impact factor: 9.941

2.  Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood.

Authors:  Anna M Aalbers; Marry M van den Heuvel-Eibrink; Irith Baumann; Michael Dworzak; Henrik Hasle; Franco Locatelli; Barbara De Moerloose; Markus Schmugge; Ester Mejstrikova; Michaela Nováková; Marco Zecca; C Michel Zwaan; Jeroen G Te Marvelde; Anton W Langerak; Jacques J M van Dongen; Rob Pieters; Charlotte M Niemeyer; Vincent H J van der Velden
Journal:  Haematologica       Date:  2014-11-25       Impact factor: 9.941

3.  Early recovery of circulating immature B cells in B-lymphoblastic leukemia patients after CD19 targeted CAR T cell therapy: A pitfall for minimal residual disease detection.

Authors:  Wenbin Xiao; Dalia Salem; Catharine S McCoy; Daniel Lee; Nirali N Shah; Maryalice Stetler-Stevenson; Constance M Yuan
Journal:  Cytometry B Clin Cytom       Date:  2017-10-31       Impact factor: 3.058

Review 4.  Immune Reconstitution After Allogeneic Haematopoietic Cell Transplantation: From Observational Studies to Targeted Interventions.

Authors:  Asaf Yanir; Ansgar Schulz; Anita Lawitschka; Stefan Nierkens; Matthias Eyrich
Journal:  Front Pediatr       Date:  2022-01-11       Impact factor: 3.418
  4 in total

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