| Literature DB >> 2357784 |
Abstract
Spironolactone (Aldactone), 100 mg to 200 mg daily, has antiandrogenic effects that may enhance treatment of androgen-excess syndromes, particularly severe hirsutism. Combination therapy with an oral contraceptive or with dexamethasone appears to have a beneficial effect. Side effects are transient. The drug should be avoided during pregnancy and in women who have a family history of breast cancer, although there is no proven association between spironolactone and breast malignancy.Entities:
Keywords: Androgens; Biology; Clinical Research; Contraception; Contraceptive Methods--therapeutic use; Diseases; Drugs--administraction and dosage; Endocrine System; Family Planning; Hirsutism--prevention and control; Hormones; Oral Contraceptives--therapeutic use; Physiology; Research Methodology; Signs And Symptoms; Testosterone; Treatment
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Year: 1990 PMID： 2357784 DOI： 10.3949/ccjm.57.3.285
Source DB: PubMed Journal: Cleve Clin J Med ISSN： 0891-1150 Impact factor: 2.321