OBJECTIVES: We present the second published case of laryngeal involvement in mitochondrial myopathy. METHODS: A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review. RESULTS: A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure. CONCLUSIONS: Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.
OBJECTIVES: We present the second published case of laryngeal involvement in mitochondrial myopathy. METHODS: A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review. RESULTS: A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure. CONCLUSIONS:Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.
Authors: Robert W Taylor; Andrew M Schaefer; Martin J Barron; Robert McFarland; Douglass M Turnbull Journal: Neuromuscul Disord Date: 2004-04 Impact factor: 4.296
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Authors: Klaus W Lange; Lara Mecklinger; Susanne Walitza; Georg Becker; Manfred Gerlach; Markus Naumann; Oliver Tucha Journal: Hum Mov Sci Date: 2006-07-21 Impact factor: 2.161