| Literature DB >> 23576430 |
Xu Wang1, Jonas Flueckiger, Shon Schmidt, Samantha Grist, Sahba T Fard, James Kirk, Matt Doerfler, Karen C Cheung, Daniel M Ratner, Lukas Chrostowski.
Abstract
We present a novel silicon photonic biosensor using phase-shifted Bragg gratings in a slot waveguide. The optical field is concentrated inside the slot region, leading to efficient light-matter interaction. The Bragg gratings are formed with sidewall corrugations on the outside of the waveguide, and a phase shift is introduced to create a sharp resonant peak within the stop band. We experimentally demonstrate a high sensitivity of 340 nm/RIU measured in salt solutions and a high quality factor of 1.5 × 10⁴, enabling a low intrinsic limit of detection of 3 × 10⁻⁴ RIU. Furthermore, the silicon device was fabricated by a CMOS foundry, facilitating high-volume and low-cost production. Finally, we demonstrate the device's ability to interrogate specific biomolecular interactions, resulting in the first of its kind label-free biosensor.Entities:
Keywords: Bragg grating; biosensor; limit of detection; microfluidics; silicon photonics; slot waveguide
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Year: 2013 PMID: 23576430 DOI: 10.1002/jbio.201300012
Source DB: PubMed Journal: J Biophotonics ISSN: 1864-063X Impact factor: 3.207