Literature DB >> 23576414

Evidence-based decision support for neurological diagnosis reduces errors and unnecessary workup.

Michael M Segal1, Marc S Williams, Andrea L Gropman, Alcy R Torres, Rob Forsyth, Anne M Connolly, Ayman W El-Hattab, Seth J Perlman, Debopam Samanta, Sumit Parikh, Steven G Pavlakis, Lynn K Feldman, Rebecca A Betensky, Sidney M Gospe.   

Abstract

Using vignettes of real cases and the SimulConsult diagnostic decision support software, neurologists listed a differential diagnosis and workup before and after using the decision support. Using the software, there was a significant reduction in error, up to 75% for diagnosis and 56% for workup. This error reduction occurred despite the baseline being one in which testers were allowed to use narrative resources and Web searching. A key factor that improved performance was taking enough time (>2 minutes) to enter clinical findings into the software accurately. Under these conditions and for instances in which the diagnoses changed based on using the software, diagnostic accuracy improved in 96% of instances. There was a 6% decrease in the number of workup items accompanied by a 34% increase in relevance. The authors conclude that decision support for a neurological diagnosis can reduce errors and save on unnecessary testing.

Entities:  

Keywords:  decision support; diagnosis; errors; genetics; medical informatics; neurogenetics

Mesh:

Year:  2013        PMID: 23576414     DOI: 10.1177/0883073813483365

Source DB:  PubMed          Journal:  J Child Neurol        ISSN: 0883-0738            Impact factor:   1.987


  9 in total

1.  User testing of a diagnostic decision support system with machine-assisted chart review to facilitate clinical genomic diagnosis.

Authors:  Alanna Kulchak Rahm; Nephi A Walton; Lynn K Feldman; Conner Jenkins; Troy Jenkins; Thomas N Person; Joeseph Peterson; Jonathon C Reynolds; Peter N Robinson; Makenzie A Woltz; Marc S Williams; Michael M Segal
Journal:  BMJ Health Care Inform       Date:  2021-05

Review 2.  The role of implementation science in improving epilepsy surgery utilization.

Authors:  Debopam Samanta
Journal:  Epilepsy Behav       Date:  2022-03-22       Impact factor: 3.337

3.  Data collaboration will lead precision medicine.

Authors:  Jason Blue-Smith
Journal:  Genom Data       Date:  2014-04-08

4.  Clinical pertinence metric enables hypothesis-independent genome-phenome analysis for neurologic diagnosis.

Authors:  Michael M Segal; Mostafa Abdellateef; Ayman W El-Hattab; Brian S Hilbush; Francisco M De La Vega; Gerard Tromp; Marc S Williams; Rebecca A Betensky; Joseph Gleeson
Journal:  J Child Neurol       Date:  2014-08-24       Impact factor: 1.987

5.  Genome interpretation: Clinical correlation is recommended.

Authors:  Michael M Segal
Journal:  Appl Transl Genom       Date:  2015-07-22

6.  An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Authors:  Catherine A Brownstein; Alan H Beggs; Nils Homer; Barry Merriman; Timothy W Yu; Katherine C Flannery; Elizabeth T DeChene; Meghan C Towne; Sarah K Savage; Emily N Price; Ingrid A Holm; Lovelace J Luquette; Elaine Lyon; Joseph Majzoub; Peter Neupert; David McCallie; Peter Szolovits; Huntington F Willard; Nancy J Mendelsohn; Renee Temme; Richard S Finkel; Sabrina W Yum; Livija Medne; Shamil R Sunyaev; Ivan Adzhubey; Christopher A Cassa; Paul I W de Bakker; Hatice Duzkale; Piotr Dworzyński; William Fairbrother; Laurent Francioli; Birgit H Funke; Monica A Giovanni; Robert E Handsaker; Kasper Lage; Matthew S Lebo; Monkol Lek; Ignaty Leshchiner; Daniel G MacArthur; Heather M McLaughlin; Michael F Murray; Tune H Pers; Paz P Polak; Soumya Raychaudhuri; Heidi L Rehm; Rachel Soemedi; Nathan O Stitziel; Sara Vestecka; Jochen Supper; Claudia Gugenmus; Bernward Klocke; Alexander Hahn; Max Schubach; Mortiz Menzel; Saskia Biskup; Peter Freisinger; Mario Deng; Martin Braun; Sven Perner; Richard J H Smith; Janeen L Andorf; Jian Huang; Kelli Ryckman; Val C Sheffield; Edwin M Stone; Thomas Bair; E Ann Black-Ziegelbein; Terry A Braun; Benjamin Darbro; Adam P DeLuca; Diana L Kolbe; Todd E Scheetz; Aiden E Shearer; Rama Sompallae; Kai Wang; Alexander G Bassuk; Erik Edens; Katherine Mathews; Steven A Moore; Oleg A Shchelochkov; Pamela Trapane; Aaron Bossler; Colleen A Campbell; Jonathan W Heusel; Anne Kwitek; Tara Maga; Karin Panzer; Thomas Wassink; Douglas Van Daele; Hela Azaiez; Kevin Booth; Nic Meyer; Michael M Segal; Marc S Williams; Gerard Tromp; Peter White; Donald Corsmeier; Sara Fitzgerald-Butt; Gail Herman; Devon Lamb-Thrush; Kim L McBride; David Newsom; Christopher R Pierson; Alexander T Rakowsky; Aleš Maver; Luca Lovrečić; Anja Palandačić; Borut Peterlin; Ali Torkamani; Anna Wedell; Mikael Huss; Andrey Alexeyenko; Jessica M Lindvall; Måns Magnusson; Daniel Nilsson; Henrik Stranneheim; Fulya Taylan; Christian Gilissen; Alexander Hoischen; Bregje van Bon; Helger Yntema; Marcel Nelen; Weidong Zhang; Jason Sager; Lu Zhang; Kathryn Blair; Deniz Kural; Michael Cariaso; Greg G Lennon; Asif Javed; Saloni Agrawal; Pauline C Ng; Komal S Sandhu; Shuba Krishna; Vamsi Veeramachaneni; Ofer Isakov; Eran Halperin; Eitan Friedman; Noam Shomron; Gustavo Glusman; Jared C Roach; Juan Caballero; Hannah C Cox; Denise Mauldin; Seth A Ament; Lee Rowen; Daniel R Richards; F Anthony San Lucas; Manuel L Gonzalez-Garay; C Thomas Caskey; Yu Bai; Ying Huang; Fang Fang; Yan Zhang; Zhengyuan Wang; Jorge Barrera; Juan M Garcia-Lobo; Domingo González-Lamuño; Javier Llorca; Maria C Rodriguez; Ignacio Varela; Martin G Reese; Francisco M De La Vega; Edward Kiruluta; Michele Cargill; Reece K Hart; Jon M Sorenson; Gholson J Lyon; David A Stevenson; Bruce E Bray; Barry M Moore; Karen Eilbeck; Mark Yandell; Hongyu Zhao; Lin Hou; Xiaowei Chen; Xiting Yan; Mengjie Chen; Cong Li; Can Yang; Murat Gunel; Peining Li; Yong Kong; Austin C Alexander; Zayed I Albertyn; Kym M Boycott; Dennis E Bulman; Paul M K Gordon; A Micheil Innes; Bartha M Knoppers; Jacek Majewski; Christian R Marshall; Jillian S Parboosingh; Sarah L Sawyer; Mark E Samuels; Jeremy Schwartzentruber; Isaac S Kohane; David M Margulies
Journal:  Genome Biol       Date:  2014-03-25       Impact factor: 13.583

7.  Evidence-based decision support for pediatric rheumatology reduces diagnostic errors.

Authors:  Michael M Segal; Balu Athreya; Mary Beth F Son; Irit Tirosh; Jonathan S Hausmann; Elizabeth Y N Ang; David Zurakowski; Lynn K Feldman; Robert P Sundel
Journal:  Pediatr Rheumatol Online J       Date:  2016-12-13       Impact factor: 3.054

8.  Experience with Integrating Diagnostic Decision Support Software with Electronic Health Records: Benefits versus Risks of Information Sharing.

Authors:  Michael M Segal; Alanna K Rahm; Nathan C Hulse; Grant Wood; Janet L Williams; Lynn Feldman; Gregory J Moore; David Gehrum; Michelle Yefko; Steven Mayernick; Roger Gildersleeve; Margie C Sunderland; Steven B Bleyl; Peter Haug; Marc S Williams
Journal:  EGEMS (Wash DC)       Date:  2017-12-06

9.  Clinician-centric diagnosis of rare genetic diseases: performance of a gene pertinence metric in decision support for clinicians.

Authors:  Michael M Segal; Renee George; Peter Waltman; Ayman W El-Hattab; Kiely N James; Valentina Stanley; Joseph Gleeson
Journal:  Orphanet J Rare Dis       Date:  2020-07-22       Impact factor: 4.123

  9 in total

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