Literature DB >> 23576123

[Deceased donor liver transplantation].

D Seehofer1, W Schöning, P Neuhaus.   

Abstract

Deceased donor liver transplantation is nowadays a routine procedure for the treatment of terminal liver failure and often represents the only chance of a cure. Under given optimal conditions excellent long-term results can be obtained with 15-year survival rates of well above 60 %.In Germany the outcome after liver transplantation has deteriorated since the introduction of an allocation policy, which is based on the medical urgency. At present 25 % of liver graft recipients die within the first year after transplantation. In contrast 1-year survival in most other countries, e.g. in the USA or the United Kingdom is around 90 % and therefore significantly better. Reasons for the inferior results in Germany are on the one hand an increasing number of critically ill recipients and on the other hand an unfavorable situation for organ donation. In comparison with other countries the organ donation rate is low and moreover the risk profile of these donors is above average. This combination of organ shortage and organ allocation represents a big challenge for the future orientation of liver transplantation and creates the potential for conflict. These cannot be solved on a medical basis but require a social consensus.Because of the present inferior results and because of the high expenses of the present system we suggest a discussion on future allocation policies as well as on future centre structures in Germany. In addition to the medical urgency the maximum benefit should also be considered for organ allocation.

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Year:  2013        PMID: 23576123     DOI: 10.1007/s00104-012-2413-8

Source DB:  PubMed          Journal:  Chirurg        ISSN: 0009-4722            Impact factor:   0.955


  24 in total

1.  The effect of the volume of procedures at transplantation centers on mortality after liver transplantation.

Authors:  E B Edwards; J P Roberts; M A McBride; J A Schulak; L G Hunsicker
Journal:  N Engl J Med       Date:  1999-12-30       Impact factor: 91.245

2.  Liver transplantation with donors over the expected lifespan in the model for end-staged liver disease era: is Mother Nature punishing us?

Authors:  Zoltan Máthé; Andreas Paul; Ernesto P Molmenti; Spiridon Vernadakis; Christian G Klein; Susanne Beckebaum; Jürgen W Treckmann; Vito R Cicinnati; László Kóbori; Georgios C Sotiropoulos
Journal:  Liver Int       Date:  2011-05-31       Impact factor: 5.828

3.  Validation of the donor risk index in orthotopic liver transplantation within the Eurotransplant region.

Authors:  Joris J Blok; Andries E Braat; Rene Adam; Andrew K Burroughs; Hein Putter; Nigel G Kooreman; Axel O Rahmel; Robert J Porte; Xavier Rogiers; Jan Ringers
Journal:  Liver Transpl       Date:  2012-01       Impact factor: 5.799

4.  The model for end-stage liver disease allocation system for liver transplantation saves lives, but increases morbidity and cost: a prospective outcome analysis.

Authors:  Philipp Dutkowski; Christian E Oberkofler; Markus Béchir; Beat Müllhaupt; Andreas Geier; Dimitri A Raptis; Pierre-Alain Clavien
Journal:  Liver Transpl       Date:  2011-06       Impact factor: 5.799

5.  Impact of center volume on outcomes of increased-risk liver transplants.

Authors:  Deepak K Ozhathil; You Fu Li; Jillian K Smith; Jennifer F Tseng; Reza F Saidi; Adel Bozorgzadeh; Shimul A Shah
Journal:  Liver Transpl       Date:  2011-10       Impact factor: 5.799

6.  The faltering solid organ donor pool in the United States (2001-2010).

Authors:  Reza F Saidi; James F Markmann; Nicolas Jabbour; YouFu Li; Shimul A Shah; A B Cosimi; Adel Bozorgzadeh
Journal:  World J Surg       Date:  2012-12       Impact factor: 3.352

7.  [Current developments in liver transplantation in Germany: MELD-based organ allocation and incentives for transplant centres].

Authors:  H J Schlitt; M Loss; M N Scherer; T Becker; K-W Jauch; B Nashan; H Schmidt; U Settmacher; X Rogiers; P Neuhaus; C Strassburg
Journal:  Z Gastroenterol       Date:  2011-01-10       Impact factor: 2.000

8.  Are there better guidelines for allocation in liver transplantation? A novel score targeting justice and utility in the model for end-stage liver disease era.

Authors:  Philipp Dutkowski; Christian E Oberkofler; Ksenija Slankamenac; Milo A Puhan; Erik Schadde; Beat Müllhaupt; Andreas Geier; Pierre A Clavien
Journal:  Ann Surg       Date:  2011-11       Impact factor: 12.969

Review 9.  Liver transplantation using fatty livers: always feasible?

Authors:  Lucas McCormack; Philipp Dutkowski; Ashraf Mohammad El-Badry; Pierre-Alain Clavien
Journal:  J Hepatol       Date:  2010-11-13       Impact factor: 25.083

10.  [Orthotopic liver transplantation. Techniques and results].

Authors:  J Schmidt; S A Müller; A Mehrabi; P Schemmer; M W Büchler
Journal:  Chirurg       Date:  2008-02       Impact factor: 0.955

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  7 in total

1.  Statistical approach to quality assessment in liver transplantation.

Authors:  Harald Schrem; Sophia Volz; Hans-Friedrich Koch; Jill Gwiasda; Priscila Kürsch; Alon Goldis; Daniel Pöhnert; Markus Winny; Jürgen Klempnauer; Alexander Kaltenborn
Journal:  Langenbecks Arch Surg       Date:  2017-09-09       Impact factor: 3.445

2.  The impact of major extended donor criteria on graft failure and patient mortality after liver transplantation.

Authors:  Vladimir J Lozanovski; Elias Khajeh; Hamidreza Fonouni; Jan Pfeiffenberger; Rebecca von Haken; Thorsten Brenner; Markus Mieth; Peter Schirmacher; Christoph W Michalski; Karl Heinz Weiss; Markus W Büchler; Arianeb Mehrabi
Journal:  Langenbecks Arch Surg       Date:  2018-08-15       Impact factor: 2.895

3.  Prognostic Abilities and Quality Assessment of Models for the Prediction of 90-Day Mortality in Liver Transplant Waiting List Patients.

Authors:  Ricardo Salinas Saldaña; Harald Schrem; Marc Barthold; Alexander Kaltenborn
Journal:  PLoS One       Date:  2017-01-27       Impact factor: 3.240

4.  Benefit in liver transplantation: a survey among medical staff, patients, medical students and non-medical university staff and students.

Authors:  Christine Englschalk; Daniela Eser; Ralf J Jox; Alexander Gerbes; Lorenz Frey; Derek A Dubay; Martin Angele; Manfred Stangl; Bruno Meiser; Jens Werner; Markus Guba
Journal:  BMC Med Ethics       Date:  2018-02-12       Impact factor: 2.652

5.  Balancing Outcome vs. Urgency in Modern Liver Transplantation.

Authors:  Peter T Dancs; Fuat H Saner; Tamas Benkö; Ernesto P Molmenti; Matthias Büchter; Andreas Paul; Dieter P Hoyer
Journal:  Front Surg       Date:  2022-03-04

6.  Volume and outcome relation in German liver transplant centers: what lessons can be learned?

Authors:  Annemarie Nijboer; Frank Ulrich; Wolf O Bechstein; Andreas A Schnitzbauer
Journal:  Transplant Res       Date:  2014-02-10

7.  Evaluating twenty-years of follow-up after orthotopic liver transplantation, best practice for donor-recipient matching: What can we learn from the past era?

Authors:  Niklas Buescher; Daniel Seehofer; Michael Helbig; Andreas Andreou; Marcus Bahra; Andreas Pascher; Johann Pratschke; Wenzel Schoening
Journal:  World J Transplant       Date:  2016-09-24
  7 in total

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